4l3n
From Proteopedia
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| - | + | ==Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus== | |
| - | + | <StructureSection load='4l3n' size='340' side='right' caption='[[4l3n]], [[Resolution|resolution]] 2.13Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4l3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_jordan-n3/2012 Human betacoronavirus 2c jordan-n3/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L3N FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1306931 Human betacoronavirus 2c Jordan-N3/2012])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l3n RCSB], [http://www.ebi.ac.uk/pdbsum/4l3n PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 77 people with a fatality rate of more than 50%. Alarmingly, the virus demonstrates a capability of human-to-human transmission, raising the possibility of global spread and endangering world health and economy. Here we have identified the receptor-binding domain (RBD) from the MERS-CoV spike protein and determined its crystal structure. This study also presents the structural comparison of MERS-CoV RBD with other coronavirus RBDs, successfully positioning MERS-CoV on the landscape of coronavirus evolution and providing insights into receptor binding by MERS-CoV. Furthermore, we found that MERS-CoV RBD functions as an effective entry inhibitor of MERS-CoV. The identified MERS-CoV RBD may also serve as a potential candidate for MERS-CoV subunit vaccines. Overall, this study enhances our understanding of the evolution of coronavirus RBDs, provides insights into receptor recognition by MERS-CoV, and may help control the transmission of MERS-CoV in humans. | ||
| - | + | Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus.,Chen Y, Rajashankar KR, Yang Y, Agnihothram SS, Liu C, Lin YL, Baric RS, Li F J Virol. 2013 Jul 31. PMID:23903833<ref>PMID:23903833</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Human betacoronavirus 2c jordan-n3/2012]] | [[Category: Human betacoronavirus 2c jordan-n3/2012]] | ||
| - | [[Category: Agnihothram, S S | + | [[Category: Agnihothram, S S]] |
| - | [[Category: Baric, R S | + | [[Category: Baric, R S]] |
| - | [[Category: Chen, Y | + | [[Category: Chen, Y]] |
| - | [[Category: Li, F | + | [[Category: Li, F]] |
| - | [[Category: Lin, Y L | + | [[Category: Lin, Y L]] |
| - | [[Category: Liu, C | + | [[Category: Liu, C]] |
| - | [[Category: Rajashankar, K R | + | [[Category: Rajashankar, K R]] |
| - | [[Category: Yang, Y | + | [[Category: Yang, Y]] |
[[Category: Beta-sheet fold]] | [[Category: Beta-sheet fold]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 15:18, 21 December 2014
Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus
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