1si7
From Proteopedia
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| - | [[Image:1si7.jpg|left|200px]] | + | [[Image:1si7.jpg|left|200px]] |
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| - | '''Structure of E. coli tRNA psi 13 pseudouridine synthase TruD''' | + | {{Structure |
| + | |PDB= 1si7 |SIZE=350|CAPTION= <scene name='initialview01'>1si7</scene>, resolution 2.20Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] | ||
| + | |GENE= TRUD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | ||
| + | }} | ||
| + | |||
| + | '''Structure of E. coli tRNA psi 13 pseudouridine synthase TruD''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SI7 is a [ | + | 1SI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SI7 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold., Kaya Y, Del Campo M, Ofengand J, Malhotra A, J Biol Chem. 2004 Apr 30;279(18):18107-10. Epub 2004 Mar 3. PMID:[http:// | + | Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold., Kaya Y, Del Campo M, Ofengand J, Malhotra A, J Biol Chem. 2004 Apr 30;279(18):18107-10. Epub 2004 Mar 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14999002 14999002] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Pseudouridylate synthase]] | [[Category: Pseudouridylate synthase]] | ||
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[[Category: trud]] | [[Category: trud]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:05:17 2008'' |
Revision as of 12:05, 20 March 2008
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| , resolution 2.20Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | TRUD (Escherichia coli) | ||||||
| Activity: | Pseudouridylate synthase, with EC number 4.2.1.70 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of E. coli tRNA psi 13 pseudouridine synthase TruD
Overview
TruD, a recently discovered novel pseudouridine synthase in Escherichia coli, is responsible for modifying uridine13 in tRNA(Glu) to pseudouridine. It has little sequence homology with the other 10 pseudouridine synthases in E. coli which themselves have been grouped into four related protein families. Crystal structure determination of TruD revealed a two domain structure consisting of a catalytic domain that differs in sequence but is structurally very similar to the catalytic domain of other pseudouridine synthases and a second large domain (149 amino acids, 43% of total) with a novel alpha/beta fold that up to now has not been found in any other protein.
About this Structure
1SI7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold., Kaya Y, Del Campo M, Ofengand J, Malhotra A, J Biol Chem. 2004 Apr 30;279(18):18107-10. Epub 2004 Mar 3. PMID:14999002
Page seeded by OCA on Thu Mar 20 14:05:17 2008
