4l5o
From Proteopedia
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| - | + | ==Crystal structure of 26 kDa GST D26H mutant of Clonorchis sinensis== | |
| - | + | <StructureSection load='4l5o' size='340' side='right' caption='[[4l5o]], [[Resolution|resolution]] 2.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4l5o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Clonorchis_sinensis Clonorchis sinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L5O FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iso|3iso]], [[4l5l|4l5l]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l5o RCSB], [http://www.ebi.ac.uk/pdbsum/4l5o PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structures of CsGST in two different space groups revealed that Asp26 and His79 coordinate a zinc ion. In one space group, His46 of an adjacent molecule participates in the coordination within 2.0A. In the other space group, Asp26, His79 and a water molecule coordinate a zinc ion. The CsGST-D26H structure showed that four histidine residues - His26 and His79 from one molecule and the same residues from a symmetry-related neighboring molecule - coordinate a zinc ion. The coordinated zinc ions are located between two molecules and mediate molecular contacts within the crystal. | ||
| - | + | Crystal structures of 26kDa Clonorchis sinensis glutathione S-transferase reveal zinc binding and putative metal binding.,Han YH, Hong SJ, Cheong HK, Chung YJ Biochem Biophys Res Commun. 2013 Aug 23;438(2):457-61. doi:, 10.1016/j.bbrc.2013.07.102. Epub 2013 Jul 31. PMID:23916611<ref>PMID:23916611</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Clonorchis sinensis]] | [[Category: Clonorchis sinensis]] | ||
| - | [[Category: Chung, Y J | + | [[Category: Chung, Y J]] |
| - | [[Category: Han, Y H | + | [[Category: Han, Y H]] |
[[Category: Gsh binding]] | [[Category: Gsh binding]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 15:36, 21 December 2014
Crystal structure of 26 kDa GST D26H mutant of Clonorchis sinensis
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