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4ka4

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{{STRUCTURE_4ka4| PDB=4ka4 | SCENE= }}
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==Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)==
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===Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)===
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<StructureSection load='4ka4' size='340' side='right' caption='[[4ka4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4ka4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KA4 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eyi|3eyi]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZBP1, C20orf183, DLM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ka4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ka4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ka4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ka4 PDBsum]</span></td></tr>
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[[4ka4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KA4 OCA].
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</table>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Athanasiadis, A.]]
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[[Category: Athanasiadis, A]]
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[[Category: Rosa, M de.]]
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[[Category: Rosa, M de]]
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[[Category: Sanctis, D De.]]
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[[Category: Sanctis, D De]]
[[Category: Dna binding protein-dna complex]]
[[Category: Dna binding protein-dna complex]]
[[Category: Dna sensor]]
[[Category: Dna sensor]]
[[Category: Whth]]
[[Category: Whth]]
[[Category: Z-dna binding]]
[[Category: Z-dna binding]]

Revision as of 15:38, 21 December 2014

Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)

4ka4, resolution 2.60Å

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