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4kpp

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{{STRUCTURE_4kpp| PDB=4kpp | SCENE= }}
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==Crystal Structure of H+/Ca2+ Exchanger CAX==
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===Crystal Structure of H+/Ca2+ Exchanger CAX===
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<StructureSection load='4kpp' size='340' side='right' caption='[[4kpp]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23704374}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4kpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_dsm_4304 Archaeoglobus fulgidus dsm 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AF0251, AF_0251 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 Archaeoglobus fulgidus DSM 4304])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpp RCSB], [http://www.ebi.ac.uk/pdbsum/4kpp PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ca2+/cation antiporters catalyze the exchange of Ca2+ with various cations across biological membranes, to regulate cytosolic calcium levels. The recently reported structure of a prokaryotic Na+/Ca2+ exchanger (NCX_Mj) revealed its overall architecture in an outward-facing state. Here we report the crystal structure of a H+/Ca2+ exchanger from Archaeoglobus fulgidus (CAX_Af) in the two representatives of the inward-facing conformation at 2.3 A resolution. The structures suggested Ca2+ or H+ binds to the cation-binding site mutually exclusively. Structural comparison of CAX_Af with NCX_Mj revealed that the first and sixth transmembrane helices alternately create hydrophilic cavities on the intra- and extracellular sides. The structures and functional analyses provide insight into the mechanism of how the inward- to outward-facing state transition is triggered by the Ca2+ and H+ binding.
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==About this Structure==
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Structural Basis for the Counter-Transport Mechanism of a H+/Ca2+ Exchanger.,Nishizawa T, Kita S, Maturana AD, Furuya N, Hirata K, Kasuya G, Ogasawara S, Dohmae N, Iwamoto T, Ishitani R, Nureki O Science. 2013 May 23. PMID:23704374<ref>PMID:23704374</ref>
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[[4kpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_dsm_4304 Archaeoglobus fulgidus dsm 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPP OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023704374</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Archaeoglobus fulgidus dsm 4304]]
[[Category: Archaeoglobus fulgidus dsm 4304]]
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[[Category: Ishitani, R.]]
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[[Category: Ishitani, R]]
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[[Category: Nishizawa, T.]]
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[[Category: Nishizawa, T]]
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[[Category: Nureki, O.]]
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[[Category: Nureki, O]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Transporter]]
[[Category: Transporter]]

Revision as of 15:38, 21 December 2014

Crystal Structure of H+/Ca2+ Exchanger CAX

4kpp, resolution 2.30Å

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