3ix0
From Proteopedia
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| - | + | ==Crystal structure of human seminal plasma protein PSP94== | |
| - | + | <StructureSection load='3ix0' size='340' side='right' caption='[[3ix0]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3ix0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IX0 FirstGlance]. <br> | |
| - | ==Disease== | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ix0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix0 PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
[[http://www.uniprot.org/uniprot/MSMB_HUMAN MSMB_HUMAN]] Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:[http://omim.org/entry/611928 611928]]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. | [[http://www.uniprot.org/uniprot/MSMB_HUMAN MSMB_HUMAN]] Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:[http://omim.org/entry/611928 611928]]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. | ||
| + | == Function == | ||
| + | |||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix0_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Several recent genome-wide association studies have linked the human MSMB gene, encoding prostate secretory protein of 94 residues (PSP94), with prostate cancer susceptibility. PSP94 is one of the most abundant proteins from prostatic secretions and a primary constituent of human semen. PSP94 suppresses tumor growth and metastasis, and its expression gradually decreases during progression of the prostate cancer. It is a rapidly evolving protein with homologues present in several species with 10 conserved cysteine residues. PSP94 homologues show high-affinity binding with different proteins from the cysteine-rich secretory protein family, some of which have been shown to be ion channel blockers. Here, we report the crystal structure of human PSP94 at 2.3 A resolution. The structure shows that the amino and the carboxyl ends of the polypeptide chain are held in close proximity facing each other. A strong hydrogen bond between these ends, which are located respectively on the first and the last beta-strands, leads to formation of an almost straight edge in PSP94 structure. Crystal structure shows that these edges from two PSP94 monomers associate in antiparallel fashion, leading to formation of a dimer. Our studies further show that dimers dissociate into monomers at acidic pH, possibly through distortion of the straight edge. Further, based on several observations, we propose that PSP94 binds to cysteine-rich secretory proteins and immunoglobulin G through the same edge, which is involved in the formation of PSP94 dimeric interface. | ||
| - | + | Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer.,Kumar A, Jagtap DD, Mahale SD, Kumar M J Mol Biol. 2010 Apr 9;397(4):947-56. Epub 2010 Feb 23. PMID:20184897<ref>PMID:20184897</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Jagtap, D D | + | [[Category: Jagtap, D D]] |
| - | [[Category: Kumar, A | + | [[Category: Kumar, A]] |
| - | [[Category: Kumar, M | + | [[Category: Kumar, M]] |
| - | [[Category: Mahale, S D | + | [[Category: Mahale, S D]] |
[[Category: Antitumor protein]] | [[Category: Antitumor protein]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
Revision as of 16:21, 21 December 2014
Crystal structure of human seminal plasma protein PSP94
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