1slt

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[[Image:1slt.jpg|left|200px]]<br /><applet load="1slt" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1slt.jpg|left|200px]]
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caption="1slt, resolution 1.9&Aring;" />
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'''STRUCTURE OF S-LECTIN, A DEVELOPMENTALLY REGULATED VERTEBRATE BETA-GALACTOSIDE BINDING PROTEIN'''<br />
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{{Structure
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|PDB= 1slt |SIZE=350|CAPTION= <scene name='initialview01'>1slt</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=CYO:OXYGENS BOUND TO CYS SG'>CYO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF S-LECTIN, A DEVELOPMENTALLY REGULATED VERTEBRATE BETA-GALACTOSIDE BINDING PROTEIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1SLT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=CYO:'>CYO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SLT OCA].
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1SLT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SLT OCA].
==Reference==
==Reference==
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Structure of S-lectin, a developmentally regulated vertebrate beta-galactoside-binding protein., Liao DI, Kapadia G, Ahmed H, Vasta GR, Herzberg O, Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1428-32. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8108426 8108426]
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Structure of S-lectin, a developmentally regulated vertebrate beta-galactoside-binding protein., Liao DI, Kapadia G, Ahmed H, Vasta GR, Herzberg O, Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1428-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8108426 8108426]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Herzberg, O.]]
[[Category: Herzberg, O.]]
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[[Category: lectin]]
[[Category: lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:02:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:06:36 2008''

Revision as of 12:06, 20 March 2008

Image:1slt.jpg


PDB ID 1slt

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF S-LECTIN, A DEVELOPMENTALLY REGULATED VERTEBRATE BETA-GALACTOSIDE BINDING PROTEIN


Overview

The crystal structure of a 14-kDa bovine spleen S-lectin complexed with the disaccharide N-acetyllactosamine at 1.9-A resolution reveals a surprising structural relationship to legume lectins, despite the lack of sequence homology. Two monomers associate to form an extended beta-sandwich, each with the same jelly roll topology typical of legume lectins but with dramatically trimmed loops and with different dimer association. Each monomer binds one N-acetyllactosamine molecule in a topologically and spatially different site than that of legume lectins. The carbohydrate-binding site provides an unprecedented paradigm for carbohydrate binding, with a unique network of salt bridges. The specificity for beta-galactose arises from intricate interactions that constrain the position of the O4 atom.

About this Structure

1SLT is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Structure of S-lectin, a developmentally regulated vertebrate beta-galactoside-binding protein., Liao DI, Kapadia G, Ahmed H, Vasta GR, Herzberg O, Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1428-32. PMID:8108426

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