1smo
From Proteopedia
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| - | [[Image:1smo.gif|left|200px]] | + | [[Image:1smo.gif|left|200px]] |
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| - | '''Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .''' | + | {{Structure |
| + | |PDB= 1smo |SIZE=350|CAPTION= <scene name='initialview01'>1smo</scene>, resolution 1.47Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=TLA:L(+)-TARTARIC ACID'>TLA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= trem-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SMO is a [ | + | 1SMO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMO OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A., Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K, Wilson IA, J Mol Biol. 2004 Sep 24;342(4):1237-48. PMID:[http:// | + | Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A., Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K, Wilson IA, J Mol Biol. 2004 Sep 24;342(4):1237-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15351648 15351648] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
[[Category: TLA]] | [[Category: TLA]] | ||
| - | [[Category: activating | + | [[Category: activating receptor]] |
[[Category: innate immune system receptor]] | [[Category: innate immune system receptor]] | ||
[[Category: structure]] | [[Category: structure]] | ||
[[Category: trem-1]] | [[Category: trem-1]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:06:59 2008'' |
Revision as of 12:06, 20 March 2008
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| , resolution 1.47Å | |||||||
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| Ligands: | |||||||
| Gene: | trem-1 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .
Overview
The triggering receptor expressed on myeloid cells (TREM) family of single extracellular immunoglobulin receptors includes both activating and inhibitory isoforms whose ligands are unknown. TREM-1 activation amplifies the Toll-like receptor initiated responses to invading pathogens allowing the secretion of pro-inflammatory chemokines and cytokines. Hence, TREM-1 amplifies the inflammation induced by both bacteria and fungi, and thus represents a potential therapeutic target. We report the crystal structure of the human TREM-1 extracellular domain at 1.47 A resolution. The overall fold places it within the V-type immunoglobulin domain family and reveals close homology with Ig domains from antibodies, T-cell receptors and other activating receptors, such as NKp44. With the additional use of analytical ultracentrifugation and 1H NMR spectroscopy of both human and mouse TREM-1, we have conclusively demonstrated the monomeric state of this extracellular ectodomain in solution and, presumably, of the TREM family in general.
About this Structure
1SMO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A., Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K, Wilson IA, J Mol Biol. 2004 Sep 24;342(4):1237-48. PMID:15351648
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