1sna

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[[Image:1sna.gif|left|200px]]<br /><applet load="1sna" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1sna.gif|left|200px]]
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caption="1sna, resolution 1.50&Aring;" />
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'''An Oligomeric Domain-Swapped Beta-Beta-Alpha Mini-Protein'''<br />
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{{Structure
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|PDB= 1sna |SIZE=350|CAPTION= <scene name='initialview01'>1sna</scene>, resolution 1.50&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> and <scene name='pdbligand=IPA:ISOPROPYL ALCOHOL'>IPA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''An Oligomeric Domain-Swapped Beta-Beta-Alpha Mini-Protein'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1SNA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ACE:'>ACE</scene>, <scene name='pdbligand=NH2:'>NH2</scene> and <scene name='pdbligand=IPA:'>IPA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNA OCA].
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1SNA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNA OCA].
==Reference==
==Reference==
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X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture., Ali MH, Peisach E, Allen KN, Imperiali B, Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12183-8. Epub 2004 Aug 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15302930 15302930]
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X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture., Ali MH, Peisach E, Allen KN, Imperiali B, Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12183-8. Epub 2004 Aug 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15302930 15302930]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Ali, M H.]]
[[Category: Ali, M H.]]
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[[Category: protein design]]
[[Category: protein design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:03:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:07:15 2008''

Revision as of 12:07, 20 March 2008

Image:1sna.gif


PDB ID 1sna

Drag the structure with the mouse to rotate
, resolution 1.50Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



An Oligomeric Domain-Swapped Beta-Beta-Alpha Mini-Protein


Overview

The x-ray crystal structure of an oligomeric miniprotein has been determined to a 1.2-A resolution by means of multiwavelength anomalous diffraction phasing with selenomethionine analogs that retain the biophysical characteristics of the native peptide. Peptide 1, comprising alpha and beta secondary structure elements with only 21 aa per monomer, associates as a discrete tetramer. The peptide adopts a previously uncharacterized quaternary structure in which alpha and beta components interact to form a tightly packed and well defined hydrophobic core. The structure provides insight into the origins of the unusual thermal stability of the oligomer. The miniprotein shares many characteristics of larger proteins, including cooperative folding, lack of 1-anilino-8-naphthalene sulfonate binding, and limited deuterium exchange, and possesses a buried surface area typical of native proteins.

About this Structure

1SNA is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture., Ali MH, Peisach E, Allen KN, Imperiali B, Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12183-8. Epub 2004 Aug 9. PMID:15302930

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