1sor
From Proteopedia
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| - | [[Image:1sor.gif|left|200px]] | + | [[Image:1sor.gif|left|200px]] |
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| - | '''Aquaporin-0 membrane junctions reveal the structure of a closed water pore''' | + | {{Structure |
| + | |PDB= 1sor |SIZE=350|CAPTION= <scene name='initialview01'>1sor</scene>, resolution 3.00Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Aquaporin-0 membrane junctions reveal the structure of a closed water pore''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SOR is a [ | + | 1SOR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOR OCA]. |
==Reference== | ==Reference== | ||
| - | Aquaporin-0 membrane junctions reveal the structure of a closed water pore., Gonen T, Sliz P, Kistler J, Cheng Y, Walz T, Nature. 2004 May 13;429(6988):193-7. PMID:[http:// | + | Aquaporin-0 membrane junctions reveal the structure of a closed water pore., Gonen T, Sliz P, Kistler J, Cheng Y, Walz T, Nature. 2004 May 13;429(6988):193-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15141214 15141214] |
[[Category: Ovis aries]] | [[Category: Ovis aries]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: water channel]] | [[Category: water channel]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:07:41 2008'' |
Revision as of 12:07, 20 March 2008
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Aquaporin-0 membrane junctions reveal the structure of a closed water pore
Overview
The lens-specific water pore aquaporin-0 (AQP0) is the only aquaporin known to form membrane junctions in vivo. We show here that AQP0 from the lens core, containing some carboxy-terminally cleaved AQP0, forms double-layered crystals that recapitulate in vivo junctions. We present the structure of the AQP0 membrane junction as determined by electron crystallography. The junction is formed by three localized interactions between AQP0 molecules in adjoining membranes, mainly mediated by proline residues conserved in AQP0s from different species but not present in most other aquaporins. Whereas all previously determined aquaporin structures show the pore in an open conformation, the water pore is closed in AQP0 junctions. The water pathway in AQP0 also contains an additional pore constriction, not seen in other known aquaporin structures, which may be responsible for pore gating.
About this Structure
1SOR is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.
Reference
Aquaporin-0 membrane junctions reveal the structure of a closed water pore., Gonen T, Sliz P, Kistler J, Cheng Y, Walz T, Nature. 2004 May 13;429(6988):193-7. PMID:15141214
Page seeded by OCA on Thu Mar 20 14:07:41 2008
