1spg

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[[Image:1spg.gif|left|200px]]<br /><applet load="1spg" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1spg.gif|left|200px]]
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caption="1spg, resolution 1.95&Aring;" />
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'''CARBONMONOXY HEMOGLOBIN FROM THE TELEOST FISH LEIOSTOMUS XANTHURUS'''<br />
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{{Structure
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|PDB= 1spg |SIZE=350|CAPTION= <scene name='initialview01'>1spg</scene>, resolution 1.95&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=CMO:CARBON MONOXIDE'>CMO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CARBONMONOXY HEMOGLOBIN FROM THE TELEOST FISH LEIOSTOMUS XANTHURUS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1SPG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Leiostomus_xanthurus Leiostomus xanthurus] with <scene name='pdbligand=ACE:'>ACE</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=CMO:'>CMO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPG OCA].
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1SPG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Leiostomus_xanthurus Leiostomus xanthurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPG OCA].
==Reference==
==Reference==
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Structural basis for the root effect in haemoglobin., Mylvaganam SE, Bonaventura C, Bonaventura J, Getzoff ED, Nat Struct Biol. 1996 Mar;3(3):275-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8605630 8605630]
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Structural basis for the root effect in haemoglobin., Mylvaganam SE, Bonaventura C, Bonaventura J, Getzoff ED, Nat Struct Biol. 1996 Mar;3(3):275-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8605630 8605630]
[[Category: Leiostomus xanthurus]]
[[Category: Leiostomus xanthurus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: teleost fish]]
[[Category: teleost fish]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:03:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:07:59 2008''

Revision as of 12:08, 20 March 2008

Image:1spg.gif


PDB ID 1spg

Drag the structure with the mouse to rotate
, resolution 1.95Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



CARBONMONOXY HEMOGLOBIN FROM THE TELEOST FISH LEIOSTOMUS XANTHURUS


Overview

The remarkable ability of root effect haemoglobins to pump oxygen against high O2 gradients results from extreme, acid-induced reductions in O2 affinity and cooperativity. The long-sought mechanism for the root effect, revealed by the 2 angstrom crystal structure of the ligand-bound haemoglobin from Leiostomus xanthurus at pH 7.5, unexpectedly involves modulation of the R-state. Key residues strategically assemble positive-charge clusters across the allosteric beta1 beta2-interface in the R-state. At low pH, protonation of the beta N terminus and His 147(HC3)beta within these clusters is postulated to destabilize the R-state and promote the acid-triggered, allosteric R-->T switch with concomitant O2 release. Surprisingly, a set of residues specific to root effect haemoglobins recruit additional residues, conserved among most haemoglobins, to produce the root effect.

About this Structure

1SPG is a Protein complex structure of sequences from Leiostomus xanthurus. Full crystallographic information is available from OCA.

Reference

Structural basis for the root effect in haemoglobin., Mylvaganam SE, Bonaventura C, Bonaventura J, Getzoff ED, Nat Struct Biol. 1996 Mar;3(3):275-83. PMID:8605630

Page seeded by OCA on Thu Mar 20 14:07:59 2008

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