This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4bkg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_4bkg| PDB=4bkg | SCENE= }}
+
==crystal structure of human diSUMO-2==
-
===crystal structure of human diSUMO-2===
+
<StructureSection load='4bkg' size='340' side='right' caption='[[4bkg]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_24151981}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4bkg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKG FirstGlance]. <br>
 +
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkg RCSB], [http://www.ebi.ac.uk/pdbsum/4bkg PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
RNF4 [RING (really interesting new gene) finger protein 4] is a SUMO-targeted ubiquitin ligase (STUbL) controlling promyelocytic leukemia (PML) nuclear bodies, DNA double strand break repair and other nuclear functions. We describe that the sequence and spacing of the SUMO-interaction motifs (SIMs) in RNF4 regulate the avidity-driven recognition of substrate proteins carrying SUMO chains of variable length.
-
==Function==
+
Multivalent interactions of the SUMO-interaction motifs in the RING-finger protein 4 (RNF4) determine the specificity for chains of the small ubiquitin-related modifier (SUMO).,Keusekotten K, Bade VN, Meyer-Teschendorf K, Sriramachandran AM, Fischer-Schrader K, Krause A, Horst C, Schwarz G, Hofmann K, Dohmen RJ, Praefcke GJ Biochem J. 2013 Oct 23. PMID:24151981<ref>PMID:24151981</ref>
-
[[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
+
-
==About this Structure==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[4bkg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKG OCA].
+
</div>
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:024151981</ref><references group="xtra"/><references/>
+
__TOC__
 +
</StructureSection>
[[Category: Human]]
[[Category: Human]]
-
[[Category: Bade, V N.]]
+
[[Category: Bade, V N]]
-
[[Category: Dohmen, R J.]]
+
[[Category: Dohmen, R J]]
-
[[Category: Fischer-Schrader, K.]]
+
[[Category: Fischer-Schrader, K]]
-
[[Category: Hofmann, K.]]
+
[[Category: Hofmann, K]]
-
[[Category: Horst, C.]]
+
[[Category: Horst, C]]
-
[[Category: Keusekotten, K.]]
+
[[Category: Keusekotten, K]]
-
[[Category: Krause, A.]]
+
[[Category: Krause, A]]
-
[[Category: Meyer-Teschendorf, K.]]
+
[[Category: Meyer-Teschendorf, K]]
-
[[Category: Praefcke, G J.K.]]
+
[[Category: Praefcke, G J.K]]
-
[[Category: Sriramachandran, A.]]
+
[[Category: Sriramachandran, A]]
[[Category: Protein binding]]
[[Category: Protein binding]]

Revision as of 16:56, 21 December 2014

crystal structure of human diSUMO-2

4bkg, resolution 2.11Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bkg"
Personal tools