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3lw3

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{{STRUCTURE_3lw3| PDB=3lw3 | SCENE= }}
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==Crystal structure of HP0420-homologue from Helicobacter felis==
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===Crystal structure of HP0420-homologue from Helicobacter felis===
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<StructureSection load='3lw3' size='340' side='right' caption='[[3lw3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20302842}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3lw3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_49179 Atcc 49179]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LW3 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lwg|3lwg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lw3 RCSB], [http://www.ebi.ac.uk/pdbsum/3lw3 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Helicobacter pylori infect more than half of the world's population and are considered a cause of peptic ulcer disease and gastric cancer. Recently, hypothetical gene HP0421 was identified in H. pylori as a cholesterol alpha-glucosyltransferase, which is required to synthesize cholesteryl glucosides, essential cell wall components of the bacteria. In the same gene-cluster, HP0420 was co-identified, whose function remains unknown. Here we report the crystal structure of HP0420-homolog of H. felis (HF0420) to gain insight into the function of HP0420. The crystal structure, combined with size-exclusion chromatography, reveals that HF0420 adopts a homodimeric hot-dog fold. The crystal structure suggests that HF0420 has enzymatic activity that involves a conserved histidine residue at the end of the central alpha-helix. Subsequent biochemical studies provide clues to the function of HP0420 and HF0420.
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==About this Structure==
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Crystal structure and functional insight of HP0420-homolog from Helicobacter felis.,Piao S, Jin XL, Yun BY, Kim N, Cho HS, Fukuda M, Lee H, Ha NC Biochem Biophys Res Commun. 2010 Apr 16;394(4):940-6. Epub 2010 Mar 17. PMID:20302842<ref>PMID:20302842</ref>
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[[3lw3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_49179 Atcc 49179]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW3 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020302842</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Atcc 49179]]
[[Category: Atcc 49179]]
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[[Category: Ha, N C.]]
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[[Category: Ha, N C]]
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[[Category: Piao, S.]]
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[[Category: Piao, S]]
[[Category: Helicobacter]]
[[Category: Helicobacter]]
[[Category: Hotdog-fold]]
[[Category: Hotdog-fold]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
[[Category: Unknown function]]

Revision as of 17:06, 21 December 2014

Crystal structure of HP0420-homologue from Helicobacter felis

3lw3, resolution 1.60Å

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