2agn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_2agn| PDB=2agn | SCENE= }}
+
==Fitting of hepatitis C virus internal ribosome entry site domains into the 15 A Cryo-EM map of a HCV IRES-80S ribosome (H. sapiens) complex==
-
===Fitting of hepatitis C virus internal ribosome entry site domains into the 15 A Cryo-EM map of a HCV IRES-80S ribosome (H. sapiens) complex===
+
<StructureSection load='2agn' size='340' side='right' caption='[[2agn]], [[Resolution|resolution]] 15.00&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_16271893}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2agn]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AGN FirstGlance]. <br>
 +
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2agn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2agn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2agn RCSB], [http://www.ebi.ac.uk/pdbsum/2agn PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Initiation of translation of the hepatitis C virus (HCV) polyprotein is driven by an internal ribosome entry site (IRES) RNA that bypasses much of the eukaryotic translation initiation machinery. Here, single-particle electron cryomicroscopy has been used to study the mechanism of HCV IRES-mediated initiation. A HeLa in vitro translation system was used to assemble human IRES-80S ribosome complexes under near physiological conditions; these were stalled before elongation. Domain 2 of the HCV IRES is bound to the tRNA exit site, touching the L1 stalk of the 60S subunit, suggesting a mechanism for the removal of the HCV IRES in the progression to elongation. Domain 3 of the HCV IRES positions the initiation codon in the ribosomal mRNA binding cleft by binding helix 28 at the head of the 40S subunit. The comparison with the previously published binary 40S-HCV IRES complex reveals structural rearrangements in the two pseudoknot structures of the HCV IRES in translation initiation.
-
==About this Structure==
+
Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES.,Boehringer D, Thermann R, Ostareck-Lederer A, Lewis JD, Stark H Structure. 2005 Nov;13(11):1695-706. PMID:16271893<ref>PMID:16271893</ref>
-
[[2agn]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AGN OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:016271893</ref><references group="xtra"/><references/>
+
</div>
-
[[Category: Boehringer, D.]]
+
== References ==
-
[[Category: Lewis, J D.]]
+
<references/>
-
[[Category: Ostareck-Lederer, A.]]
+
__TOC__
-
[[Category: Stark, H.]]
+
</StructureSection>
-
[[Category: Thermann, R.]]
+
[[Category: Boehringer, D]]
 +
[[Category: Lewis, J D]]
 +
[[Category: Ostareck-Lederer, A]]
 +
[[Category: Stark, H]]
 +
[[Category: Thermann, R]]
[[Category: Hcv]]
[[Category: Hcv]]
[[Category: Ire]]
[[Category: Ire]]
[[Category: Rna]]
[[Category: Rna]]

Revision as of 17:13, 21 December 2014

Fitting of hepatitis C virus internal ribosome entry site domains into the 15 A Cryo-EM map of a HCV IRES-80S ribosome (H. sapiens) complex

2agn, resolution 15.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2agn"
Personal tools