4l01
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the V658F apo Jak1 pseudokinase domain== | |
| - | + | <StructureSection load='4l01' size='340' side='right' caption='[[4l01]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4l01]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L01 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l00|4l00]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JAK1, JAK1A, JAK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l01 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l01 RCSB], [http://www.ebi.ac.uk/pdbsum/4l01 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The V617F mutation in the Jak2 pseudokinase domain causes myeloproliferative neoplasms, and the equivalent mutation in Jak1 (V658F) is found in T-cell leukemias. Crystal structures of wild-type and V658F-mutant human Jak1 pseudokinase reveal a conformational switch that remodels a linker segment encoded by exon 12, which is also a site of mutations in Jak2. This switch is required for V617F-mediated Jak2 activation and possibly for physiologic Jak activation. | ||
| - | + | Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.,Toms AV, Deshpande A, McNally R, Jeong Y, Rogers JM, Kim CU, Gruner SM, Ficarro SB, Marto JA, Sattler M, Griffin JD, Eck MJ Nat Struct Mol Biol. 2013 Sep 8. doi: 10.1038/nsmb.2673. PMID:24013208<ref>PMID:24013208</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | + | *[[Janus kinase|Janus kinase]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
| - | [[Category: Eck, M J | + | [[Category: Eck, M J]] |
| - | [[Category: Rogers, J M | + | [[Category: Rogers, J M]] |
| - | [[Category: Toms, A V | + | [[Category: Toms, A V]] |
[[Category: Kinase domain fold]] | [[Category: Kinase domain fold]] | ||
[[Category: Regulatory]] | [[Category: Regulatory]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 17:29, 21 December 2014
Crystal structure of the V658F apo Jak1 pseudokinase domain
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