4nzu
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the primary monoclonal antibody 13PL Fab' from a multiple myeloma patient== | |
| - | + | <StructureSection load='4nzu' size='340' side='right' caption='[[4nzu]], [[Resolution|resolution]] 1.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4nzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZU FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nzr|4nzr]], [[4nzt|4nzt]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzu RCSB], [http://www.ebi.ac.uk/pdbsum/4nzu PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known protein structures, as does its mechanism of antibody binding. Protein M binds with high affinity to all types of human and nonhuman immunoglobulin G, predominantly through attachment to the conserved portions of the variable region of the kappa and lambda light chains. Protein M blocks antibody-antigen union, likely because of its large C-terminal domain extending over the antibody-combining site, blocking entry to large antigens. Similar to the other immunoglobulin-binding proteins such as Protein A, Protein M as well as its orthologs in other Mycoplasma species could become invaluable reagents in the antibody field. | ||
| - | + | A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.,Grover RK, Zhu X, Nieusma T, Jones T, Boero I, MacLeod AS, Mark A, Niessen S, Kim HJ, Kong L, Assad-Garcia N, Kwon K, Chesi M, Smider VV, Salomon DR, Jelinek DF, Kyle RA, Pyles RB, Glass JI, Ward AB, Wilson IA, Lerner RA Science. 2014 Feb 7;343(6171):656-61. doi: 10.1126/science.1246135. PMID:24503852<ref>PMID:24503852</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Wilson, I A | + | [[Category: Wilson, I A]] |
| - | [[Category: Zhu, X | + | [[Category: Zhu, X]] |
[[Category: Antibody fab]] | [[Category: Antibody fab]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Multiple myeloma]] | [[Category: Multiple myeloma]] | ||
[[Category: Primary antibody]] | [[Category: Primary antibody]] | ||
Revision as of 17:35, 21 December 2014
Crystal structure of the primary monoclonal antibody 13PL Fab' from a multiple myeloma patient
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