4gm9

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{{STRUCTURE_4gm9| PDB=4gm9 | SCENE= }}
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==Crystal structure of human WD repeat domain 5 with compound MM-401==
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===Crystal structure of human WD repeat domain 5 with compound MM-401===
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<StructureSection load='4gm9' size='340' side='right' caption='[[4gm9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4gm9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GM9 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XO:2-METHYL-D-LYSINE'>0XO</scene>, <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=ALQ:2-METHYL-PROPIONIC+ACID'>ALQ</scene>, <scene name='pdbligand=PG9:D-PHENYLGLYCINE'>PG9</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gm3|4gm3]], [[4gm8|4gm8]], [[4gmb|4gmb]]</td></tr>
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==About this Structure==
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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[[4gm9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GM9 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gm9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gm9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gm9 PDBsum]</span></td></tr>
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</table>
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==Reference==
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__TOC__
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<references group="xtra"/><references/>
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</StructureSection>
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[[Category: Bernard, D.]]
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[[Category: Human]]
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[[Category: Chen, Y.]]
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[[Category: Bernard, D]]
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[[Category: Dou, Y.]]
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[[Category: Chen, Y]]
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[[Category: Karatas, H.]]
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[[Category: Dou, Y]]
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[[Category: Lei, M.]]
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[[Category: Karatas, H]]
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[[Category: Liu, L.]]
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[[Category: Lei, M]]
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[[Category: Townsend, E C.]]
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[[Category: Liu, L]]
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[[Category: Townsend, E C]]
[[Category: Wang, S]]
[[Category: Wang, S]]
[[Category: Histone methyltransferase]]
[[Category: Histone methyltransferase]]

Revision as of 17:40, 21 December 2014

Crystal structure of human WD repeat domain 5 with compound MM-401

4gm9, resolution 2.10Å

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