1svb

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[[Image:1svb.gif|left|200px]]<br /><applet load="1svb" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1svb.gif|left|200px]]
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caption="1svb, resolution 1.9&Aring;" />
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'''ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS'''<br />
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{{Structure
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|PDB= 1svb |SIZE=350|CAPTION= <scene name='initialview01'>1svb</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1SVB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVB OCA].
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1SVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVB OCA].
==Reference==
==Reference==
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The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7753193 7753193]
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The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7753193 7753193]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Tick-borne encephalitis virus]]
[[Category: Tick-borne encephalitis virus]]
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[[Category: glycoprotein]]
[[Category: glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:05:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:10:04 2008''

Revision as of 12:10, 20 March 2008

Image:1svb.gif


PDB ID 1svb

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS


Overview

The crystallographically determined structure of a soluble fragment from the major envelope protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a direction that would be parallel to the viral membrane. Residues that influence binding of monoclonal antibodies lie on the outward-facing surface of the protein. The clustering of mutations that affect virulence in various flaviviruses indicates a possible receptor binding site and, together with other mutational and biochemical data, suggests a picture for the fusion-activating, conformational change triggered by low pH.

About this Structure

1SVB is a Single protein structure of sequence from Tick-borne encephalitis virus. Full crystallographic information is available from OCA.

Reference

The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:7753193

Page seeded by OCA on Thu Mar 20 14:10:04 2008

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