1sw6
From Proteopedia
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| - | [[Image:1sw6.gif|left|200px]] | + | [[Image:1sw6.gif|left|200px]] |
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| - | '''S. CEREVISIAE SWI6 ANKYRIN-REPEAT FRAGMENT''' | + | {{Structure |
| + | |PDB= 1sw6 |SIZE=350|CAPTION= <scene name='initialview01'>1sw6</scene>, resolution 2.10Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= SWI6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | }} | ||
| + | |||
| + | '''S. CEREVISIAE SWI6 ANKYRIN-REPEAT FRAGMENT''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SW6 is a [ | + | 1SW6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SW6 OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray structural analysis of the yeast cell cycle regulator Swi6 reveals variations of the ankyrin fold and has implications for Swi6 function., Foord R, Taylor IA, Sedgwick SG, Smerdon SJ, Nat Struct Biol. 1999 Feb;6(2):157-65. PMID:[http:// | + | X-ray structural analysis of the yeast cell cycle regulator Swi6 reveals variations of the ankyrin fold and has implications for Swi6 function., Foord R, Taylor IA, Sedgwick SG, Smerdon SJ, Nat Struct Biol. 1999 Feb;6(2):157-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10048928 10048928] |
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Smerdon, S J.]] | [[Category: Smerdon, S J.]] | ||
[[Category: Taylor, I A.]] | [[Category: Taylor, I A.]] | ||
| - | [[Category: ankyrin | + | [[Category: ankyrin repeat]] |
[[Category: cell-cycle]] | [[Category: cell-cycle]] | ||
[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:10:25 2008'' |
Revision as of 12:10, 20 March 2008
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| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | SWI6 (Saccharomyces cerevisiae) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
S. CEREVISIAE SWI6 ANKYRIN-REPEAT FRAGMENT
Overview
Swi6 is a 92,000 Mr protein common to two distinct transcriptional activation complexes (SBF and MBF) that coordinate gene expression at the G1-S boundary of the yeast cell cycle. The X-ray structure of a central 36,000 Mr fragment has been determined and refined at 2.1 A resolution. The structure reveals a basic framework of five ankyrin repeat modules that is elaborated through a series of helical insertions distinguishing it from structures of other ankyrin repeat proteins. A second domain contains an approximately 30-residue region of extended structure that interacts with the ankyrin repeat core over a substantial proportion of its surface. Conservation of residues buried by these interactions indicates that all members of the Swi6/Cdc10 family share a similar architecture. Several temperature-sensitive mutations within Swi6 and Cdc10 appear to disrupt these interdomain contacts rather than destabilize the ankyrin repeat core. The unusual domain arrangement may be crucial for the modulation of interactions with other co-regulatory molecules such as cyclin-CDK complexes, and has implications for the quaternary interactions within the multisubunit SBF and MBF transcription complexes.
About this Structure
1SW6 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
X-ray structural analysis of the yeast cell cycle regulator Swi6 reveals variations of the ankyrin fold and has implications for Swi6 function., Foord R, Taylor IA, Sedgwick SG, Smerdon SJ, Nat Struct Biol. 1999 Feb;6(2):157-65. PMID:10048928
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