4my1

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{{STRUCTURE_4my1| PDB=4my1 | SCENE= }}
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==Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Bacillus anthracis str. Ames complexed with P68==
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===Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Bacillus anthracis str. Ames complexed with P68===
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<StructureSection load='4my1' size='340' side='right' caption='[[4my1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4my1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MY1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=P68:1-(4-BROMOPHENYL)-3-(2-{3-[(1E)-N-HYDROXYETHANIMIDOYL]PHENYL}PROPAN-2-YL)UREA'>P68</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tsb|3tsb]], [[3tsd|3tsd]], [[3usb|3usb]], [[4mjm|4mjm]], [[4mxs|4mxs]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAS0011, BA_0008, GBAA_0008, guaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4my1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4my1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4my1 RCSB], [http://www.ebi.ac.uk/pdbsum/4my1 PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/Q81W29_BACAN Q81W29_BACAN]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
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*[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4my1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY1 OCA].
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[[Category: IMP dehydrogenase]]
[[Category: IMP dehydrogenase]]
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[[Category: Anderson, W F.]]
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[[Category: Anderson, W F]]
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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[[Category: Structural genomic]]
[[Category: Csgid]]
[[Category: Csgid]]
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[[Category: Gu, M.]]
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[[Category: Gu, M]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak, A]]
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[[Category: Kim, Y.]]
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[[Category: Kim, Y]]
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[[Category: Makowska-Grzyska, M.]]
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[[Category: Makowska-Grzyska, M]]
[[Category: Alpha-beta structure]]
[[Category: Alpha-beta structure]]
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[[Category: Center for structural genomics of infectious disease]]
 
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[[Category: Csgid]]
 
[[Category: National institute of allergy and infectious disease]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Niaid]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Structural genomic]]
 
[[Category: Tim-barrel]]
[[Category: Tim-barrel]]

Revision as of 17:55, 21 December 2014

Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Bacillus anthracis str. Ames complexed with P68

4my1, resolution 2.60Å

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