3hj6

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{{STRUCTURE_3hj6| PDB=3hj6 | SCENE= }}
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==Structure of Halothermothrix orenii fructokinase (FRK)==
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===Structure of Halothermothrix orenii fructokinase (FRK)===
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<StructureSection load='3hj6' size='340' side='right' caption='[[3hj6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20493950}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hj6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloh Haloh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HJ6 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructokinase Fructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.4 2.7.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hj6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hj6 RCSB], [http://www.ebi.ac.uk/pdbsum/3hj6 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/3hj6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fructokinase (FRK; EC 2.7.1.4) catalyzes the phosphorylation of d-fructose to d-fructose 6-phosphate (F6P). This irreversible and near rate-limiting step is a central and regulatory process in plants and bacteria, which channels fructose into a metabolically active state for glycolysis. Towards understanding the mechanism of FRK, here we report the crystal structure of a FRK homolog from a thermohalophilic bacterium Halothermothrixorenii (Hore_18220 in sequence databases). The structure of the Hore_18220 protein reveals a catalytic domain with a Rossmann-like fold and a beta-sheet "lid" for dimerization. Based on comparison of Hore_18220 to structures of related proteins, we propose its mechanism of action, in which the lid serves to regulate access to the substrate binding sites. Close relationship of Hore_18220 and plant FRK enzymes allows us to propose a model for the structure and function of FRKs.
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==About this Structure==
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Crystal structure of a fructokinase homolog from Halothermothrix orenii.,Chua TK, Seetharaman J, Kasprzak JM, Ng C, Patel BK, Love C, Bujnicki JM, Sivaraman J J Struct Biol. 2010 Sep;171(3):397-401. Epub 2010 May 21. PMID:20493950<ref>PMID:20493950</ref>
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[[3hj6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloh Haloh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJ6 OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[Fructokinase|Fructokinase]]
*[[Fructokinase|Fructokinase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020493950</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Fructokinase]]
[[Category: Fructokinase]]
[[Category: Haloh]]
[[Category: Haloh]]
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[[Category: Bujnicki, J M.]]
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[[Category: Bujnicki, J M]]
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[[Category: Chua, T K.]]
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[[Category: Chua, T K]]
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[[Category: Kasprzak, J M.]]
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[[Category: Kasprzak, J M]]
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[[Category: Love, C.]]
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[[Category: Love, C]]
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[[Category: Ng, C.]]
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[[Category: Ng, C]]
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[[Category: Patel, B K.]]
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[[Category: Patel, B K]]
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[[Category: Seetharaman, J.]]
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[[Category: Seetharaman, J]]
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[[Category: Sivaraman, J.]]
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[[Category: Sivaraman, J]]
[[Category: Carbohydrate metabolism]]
[[Category: Carbohydrate metabolism]]
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[[Category: Fructokinase]]
 
[[Category: Fructose]]
[[Category: Fructose]]
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 17:56, 21 December 2014

Structure of Halothermothrix orenii fructokinase (FRK)

3hj6, resolution 2.80Å

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