4mya

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{{STRUCTURE_4mya| PDB=4mya | SCENE= }}
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==Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor A110==
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===Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor A110===
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<StructureSection load='4mya' size='340' side='right' caption='[[4mya]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4mya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MYA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2EY:4-{(1R)-1-[1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOL-4-YL]ETHOXY}QUINOLIN-2(1H)-ONE'>2EY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3stb|3stb]], [[3std|3std]], [[3sub|3sub]], [[4mjm|4mjm]], [[4mxs|4mxs]], [[4my1|4my1]], [[4my8|4my8]], [[4my9|4my9]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">guaB, BA_0008, BAS0011, GBAA_0008 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mya RCSB], [http://www.ebi.ac.uk/pdbsum/4mya PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/Q81W29_BACAN Q81W29_BACAN]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
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*[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4mya]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MYA OCA].
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[[Category: IMP dehydrogenase]]
[[Category: IMP dehydrogenase]]
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[[Category: Anderson, W F.]]
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[[Category: Anderson, W F]]
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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[[Category: Structural genomic]]
[[Category: Csgid]]
[[Category: Csgid]]
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[[Category: Gu, M.]]
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[[Category: Gu, M]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak, A]]
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[[Category: Kim, Y.]]
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[[Category: Kim, Y]]
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[[Category: Makowska-Grzyska, M.]]
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[[Category: Makowska-Grzyska, M]]
[[Category: Alpha-beta structure]]
[[Category: Alpha-beta structure]]
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[[Category: Center for structural genomics of infectious disease]]
 
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[[Category: Csgid]]
 
[[Category: National institute of allergy and infectious disease]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Niaid]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Structural genomic]]
 
[[Category: Tim barrel]]
[[Category: Tim barrel]]

Revision as of 17:58, 21 December 2014

Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor A110

4mya, resolution 1.90Å

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