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4me3
From Proteopedia
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| - | + | ==1.8 Angstrom Crystal Structure of the N-terminal Domain of an Archaeal MCM== | |
| - | + | <StructureSection load='4me3' size='340' side='right' caption='[[4me3]], [[Resolution|resolution]] 1.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4me3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ME3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ME3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ta0799 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 "Thermoplasma acidophila" (sic) Darland et al. 1970])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4me3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4me3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4me3 RCSB], [http://www.ebi.ac.uk/pdbsum/4me3 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mini-chromosome maintenance (MCM) proteins are the replicative helicase necessary for DNA replication in both eukarya and archaea. Most of archaea only have one MCM gene. Here, we report a 1.8-A crystal structure of the N-terminal MCM from the archaeon Thermoplasma acidophilum (tapMCM). In the structure, the MCM N-terminus forms a right-handed filament that contains six subunits in each turn, with a diameter of 25A of the central channel opening. The inner surface is highly positively charged, indicating DNA binding. This filament structure with six subunits per turn may also suggests a potential role for an open-ring structure for hexameric MCM and dynamic conformational changes in initiation and elongation stages of DNA replication. | ||
| - | + | The 1.8-A Crystal Structure of the N-Terminal Domain of an Archaeal MCM as a Right-Handed Filament.,Fu Y, Slaymaker IM, Wang J, Wang G, Chen XS J Mol Biol. 2013 Dec 27. pii: S0022-2836(13)00812-7. doi:, 10.1016/j.jmb.2013.12.025. PMID:24378617<ref>PMID:24378617</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Chen, X S | + | == References == |
| - | [[Category: Fu, Y | + | <references/> |
| - | [[Category: Slaymaker, I M | + | __TOC__ |
| - | [[Category: Wang, G | + | </StructureSection> |
| + | [[Category: Chen, X S]] | ||
| + | [[Category: Fu, Y]] | ||
| + | [[Category: Slaymaker, I M]] | ||
| + | [[Category: Wang, G]] | ||
[[Category: Aaa+]] | [[Category: Aaa+]] | ||
[[Category: Helicase]] | [[Category: Helicase]] | ||
[[Category: Replication]] | [[Category: Replication]] | ||
[[Category: Zinc binding domain]] | [[Category: Zinc binding domain]] | ||
Revision as of 17:59, 21 December 2014
1.8 Angstrom Crystal Structure of the N-terminal Domain of an Archaeal MCM
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Categories: Chen, X S | Fu, Y | Slaymaker, I M | Wang, G | Aaa+ | Helicase | Replication | Zinc binding domain
