4bmj

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{{STRUCTURE_4bmj| PDB=4bmj | SCENE= }}
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==Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1==
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===Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1===
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<StructureSection load='4bmj' size='340' side='right' caption='[[4bmj]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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{{ABSTRACT_PUBMED_24239949}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bmj]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BMJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bmj RCSB], [http://www.ebi.ac.uk/pdbsum/4bmj PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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TAX1BP1 is a novel ubiquitin-binding adaptor protein involved in the negative regulation of the NF-kappaB transcription factor, which is a key player in inflammatory responses, immunity and tumorigenesis. TAX1BP1 recruits A20 to the ubiquitinated signaling proteins TRAF6 and RIP1, leading to their A20-mediated deubiquitination and the disruption of IL-1-induced and TNF-induced NF-kappaB signaling, respectively. The two zinc fingers localized at its C-terminus function as novel ubiquitin-binding domains (UBZ, ubiquitin-binding zinc finger). Here we present for the first time both the solution and crystal structures of two classical UBZ domains in tandem within the human TAX1BP1. The relative orientation of the two domains is slightly different in the X-ray structure with respect to the NMR structure, indicating some degree of conformational flexibility, which is rationalized by NMR relaxation data. The observed degree of flexibility and stability between the two UBZ domains might have consequences on the recognition mechanism of interacting partners.
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==Function==
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The Structure of TAX1BP1 UBZ1+2 Provides Insight into Target Specificity and Adaptability.,Ceregido MA, Spinola Amilibia M, Buts L, Rivera-Torres J, Garcia-Pino A, Bravo J, van Nuland NA J Mol Biol. 2013 Nov 13. pii: S0022-2836(13)00717-1. doi:, 10.1016/j.jmb.2013.11.006. PMID:24239949<ref>PMID:24239949</ref>
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[[http://www.uniprot.org/uniprot/TAXB1_HUMAN TAXB1_HUMAN]] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.<ref>PMID:10435631</ref> <ref>PMID:10920205</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4bmj]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMJ OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024239949</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Bravo, J.]]
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[[Category: Bravo, J]]
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[[Category: Buts, L.]]
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[[Category: Buts, L]]
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[[Category: Ceregido, M A.]]
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[[Category: Ceregido, M A]]
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[[Category: Nuland, N A.J van.]]
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[[Category: Nuland, N A.J van]]
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[[Category: Rivera, J.]]
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[[Category: Rivera, J]]
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[[Category: Spinola-Amilibia, M.]]
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[[Category: Spinola-Amilibia, M]]
[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Inflammation]]
[[Category: Inflammation]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
[[Category: Ubz domain]]
[[Category: Ubz domain]]

Revision as of 18:06, 21 December 2014

Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1

4bmj, resolution 2.75Å

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