3wg2

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{{STRUCTURE_3wg2| PDB=3wg2 | SCENE= }}
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==Crystal structure of Agrocybe cylindracea galectin mutant (N46A)==
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===Crystal structure of Agrocybe cylindracea galectin mutant (N46A)===
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<StructureSection load='3wg2' size='340' side='right' caption='[[3wg2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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{{ABSTRACT_PUBMED_24036446}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3wg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WG2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wg1|3wg1]], [[3wg3|3wg3]], [[3wg4|3wg4]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wg2 RCSB], [http://www.ebi.ac.uk/pdbsum/3wg2 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A fungal galectin from Agrocybe cylindracea (ACG) exhibits broad binding specificity for beta-galactose-containing glycans. We determined the crystal structures of wild-type ACG and the N46A mutant, with and without glycan ligands. From these structures and a saccharide-binding analysis of the N46A mutant, we revealed that a conformational change of a unique insertion sequence containing Asn46 provides two binding modes for ACG, and thereby confers broad binding specificity. We propose that the unique sequence provides these two distinct glycan-binding modes by an induced-fit mechanism.
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==About this Structure==
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Conformational change of a unique sequence in a fungal galectin from Agrocybe cylindracea controls glycan ligand-binding specificity.,Kuwabara N, Hu D, Tateno H, Makyio H, Hirabayashi J, Kato R FEBS Lett. 2013 Nov 15;587(22):3620-5. doi: 10.1016/j.febslet.2013.08.046. Epub, 2013 Sep 10. PMID:24036446<ref>PMID:24036446</ref>
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[[3wg2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG2 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024036446</ref><references group="xtra"/><references/>
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</div>
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[[Category: Hirabayashi, J.]]
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== References ==
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[[Category: Hu, D.]]
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<references/>
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[[Category: Kato, R.]]
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__TOC__
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[[Category: Kuwabara, N.]]
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</StructureSection>
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[[Category: Makio, H.]]
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[[Category: Agrae]]
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[[Category: Tateno, H.]]
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[[Category: Hirabayashi, J]]
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[[Category: Hu, D]]
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[[Category: Kato, R]]
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[[Category: Kuwabara, N]]
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[[Category: Makio, H]]
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[[Category: Tateno, H]]
[[Category: Galactose binding]]
[[Category: Galactose binding]]
[[Category: Galectin]]
[[Category: Galectin]]
[[Category: Sugar binding protein]]
[[Category: Sugar binding protein]]

Revision as of 18:08, 21 December 2014

Crystal structure of Agrocybe cylindracea galectin mutant (N46A)

3wg2, resolution 2.20Å

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