4mz9

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{{STRUCTURE_4mz9| PDB=4mz9 | SCENE= }}
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==Revised structure of E. coli SSB==
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===Revised structure of E. coli SSB===
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<StructureSection load='4mz9' size='340' side='right' caption='[[4mz9]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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{{ABSTRACT_PUBMED_10731701}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4mz9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZ9 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qvc|1qvc]], [[1sru|1sru]], [[1eyg|1eyg]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b4059, exrB, JW4020, lexC, ssb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mz9 RCSB], [http://www.ebi.ac.uk/pdbsum/4mz9 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The single-stranded DNA (ssDNA) binding protein from Escherichia coli (EcoSSB) plays a central role in DNA replication, recombination and repair. The tertiary structure of EcoSSB was determined at 2.2 A resolution. This is rather higher resolution than previously reported. Crystals were grown from the homogeneous intact protein but the EcoSSB tetramer in the crystals contains truncated subunits lacking a part of the C-terminal. The structure determined includes biologically important flexible loops and C-terminal regions, and revealed the existence of concavities. These concavities include the residues important for ssDNA binding. An ssDNA can be fitted on the concavities and further stabilized through interactions with the loops forming flexible lids. It seems likely to play a central role in the binding of ssDNA.
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==Function==
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Roles of functional loops and the C-terminal segment of a single-stranded DNA binding protein elucidated by X-Ray structure analysis.,Matsumoto T, Morimoto Y, Shibata N, Kinebuchi T, Shimamoto N, Tsukihara T, Yasuoka N J Biochem. 2000 Feb;127(2):329-35. PMID:10731701<ref>PMID:10731701</ref>
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[[http://www.uniprot.org/uniprot/SSB_ECOLI SSB_ECOLI]] This protein is essential for replication of the chromosomes and its single-stranded DNA phages. It is also involved in DNA recombination and repair.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4mz9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ9 OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010731701</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Oakley, A J.]]
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</StructureSection>
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[[Category: Ecoli]]
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[[Category: Oakley, A J]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Dnag]]
[[Category: Dnag]]

Revision as of 18:21, 21 December 2014

Revised structure of E. coli SSB

4mz9, resolution 2.20Å

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