4k8u

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{{STRUCTURE_4k8u| PDB=4k8u | SCENE= }}
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==Crystal structure of TRAF4 TRAF domain==
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===Crystal structure of TRAF4 TRAF domain===
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<StructureSection load='4k8u' size='340' side='right' caption='[[4k8u]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K8U FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRAF4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [http://www.ebi.ac.uk/pdbsum/4k8u PDBsum]</span></td></tr>
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==About this Structure==
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</table>
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[[4k8u]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Human]]
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<references group="xtra"/><references/>
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[[Category: Park, H H]]
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[[Category: Park, H H.]]
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[[Category: Yoon, J H]]
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[[Category: Yoon, J H.]]
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[[Category: Protein interaction]]
[[Category: Protein interaction]]
[[Category: Signaling molecule binding]]
[[Category: Signaling molecule binding]]

Revision as of 18:25, 21 December 2014

Crystal structure of TRAF4 TRAF domain

4k8u, resolution 2.30Å

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