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4nqm
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand== | |
| - | + | <StructureSection load='4nqm' size='340' side='right' caption='[[4nqm]], [[Resolution|resolution]] 1.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[4nqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NQM FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=Y1Z:2-CHLORO-N-[5-(3-METHYL[1,2,4]TRIAZOLO[3,4-A]PHTHALAZIN-6-YL)-2-(MORPHOLIN-4-YL)PHENYL]BENZENESULFONAMIDE'>Y1Z</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nqn|4nqn]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nqm RCSB], [http://www.ebi.ac.uk/pdbsum/4nqm PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| - | + | == Function == | |
| - | ==Function== | + | |
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Human]] | |
| - | <references | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Bountra, C]] |
| - | [[Category: Bountra, C | + | [[Category: Delft, F von]] |
| - | [[Category: Delft, F von | + | [[Category: Edwards, A M]] |
| - | [[Category: Edwards, A M | + | [[Category: Fedorov, O]] |
| - | [[Category: Fedorov, O | + | [[Category: Felletar, I]] |
| - | [[Category: Felletar, I | + | [[Category: Filippakopoulos, P]] |
| - | [[Category: Filippakopoulos, P | + | [[Category: Knapp, S]] |
| - | [[Category: Knapp, S | + | [[Category: Martin, S]] |
| - | [[Category: Martin, S | + | [[Category: Picaud, S]] |
| - | [[Category: Picaud, S | + | [[Category: Structural genomic]] |
| - | [[Category: | + | |
[[Category: Bromodomain]] | [[Category: Bromodomain]] | ||
[[Category: Inhibition]] | [[Category: Inhibition]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Small molecule inhibitor]] | [[Category: Small molecule inhibitor]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription-inhibitor complex]] | [[Category: Transcription-inhibitor complex]] | ||
Revision as of 18:29, 21 December 2014
Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand
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