1szw
From Proteopedia
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| - | [[Image:1szw.gif|left|200px]] | + | [[Image:1szw.gif|left|200px]] |
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| - | '''Crystal structure of E. coli tRNA pseudouridine synthase TruD''' | + | {{Structure |
| + | |PDB= 1szw |SIZE=350|CAPTION= <scene name='initialview01'>1szw</scene>, resolution 2.00Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] | ||
| + | |GENE= TRUD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of E. coli tRNA pseudouridine synthase TruD''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SZW is a [ | + | 1SZW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZW OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold., Ericsson UB, Nordlund P, Hallberg BM, FEBS Lett. 2004 May 7;565(1-3):59-64. PMID:[http:// | + | X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold., Ericsson UB, Nordlund P, Hallberg BM, FEBS Lett. 2004 May 7;565(1-3):59-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15135053 15135053] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Pseudouridylate synthase]] | [[Category: Pseudouridylate synthase]] | ||
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[[Category: rna modification]] | [[Category: rna modification]] | ||
[[Category: spine]] | [[Category: spine]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
[[Category: trud]] | [[Category: trud]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:11:49 2008'' |
Revision as of 12:11, 20 March 2008
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| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | TRUD (Escherichia coli) | ||||||
| Activity: | Pseudouridylate synthase, with EC number 4.2.1.70 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of E. coli tRNA pseudouridine synthase TruD
Overview
Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine in structural RNA. The pseudouridine synthase TruD, that modifies U13 in tRNA, belongs to a recently identified and large family of pseudouridine synthases present in all kingdoms of life. We report here the crystal structure of Escherichia coli TruD at 2.0 A resolution. The structure reveals an overall V-shaped molecule with an RNA-binding cleft formed between two domains: a catalytic domain and an insertion domain. The catalytic domain has a fold similar to that of the catalytic domains of previously characterised pseudouridine synthases, whereas the insertion domain displays a novel fold.
About this Structure
1SZW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold., Ericsson UB, Nordlund P, Hallberg BM, FEBS Lett. 2004 May 7;565(1-3):59-64. PMID:15135053
Page seeded by OCA on Thu Mar 20 14:11:49 2008
