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4l8t
From Proteopedia
(Difference between revisions)
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| - | + | ==Structure of the Cargo Binding Domain from Human Myosin Vc== | |
| - | + | <StructureSection load='4l8t' size='340' side='right' caption='[[4l8t]], [[Resolution|resolution]] 2.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4l8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8T FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j5l|4j5l]], [[4j5m|4j5m]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MYO5C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8t RCSB], [http://www.ebi.ac.uk/pdbsum/4l8t PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Myosin V (MyoV) motors have been implicated in the intracellular transport of diverse cargoes including vesicles, organelles, RNA-protein complexes and regulatory proteins. Here, we have solved the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD dimerization process, which is unique for the MyoVc subclass. Moreover, the cargo- and motor-binding sites were structurally assigned indicating the conservation of residues involved in the recognition of adaptors for peroxisome transport and providing high-resolution insights into motor domain (MD) inhibition by CBD. These results contribute to understanding the structural requirements for cargo transport, auto-inhibition and regulatory mechanisms in myosin V motors. | ||
| - | + | Structural insights into functional overlapping and differentiation among myosin V motors.,Nascimento AF, Trindade DM, Tonoli CC, de Giuseppe PO, Assis LH, Honorato RV, de Oliveira PS, Mahajan P, Burgess-Brown NA, von Delft F, Larson RE, Murakami MT J Biol Chem. 2013 Oct 4. PMID:24097982<ref>PMID:24097982</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | + | *[[Myosin|Myosin]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: Assis, L H.P | + | [[Category: Assis, L H.P]] |
| - | [[Category: Berridge, G | + | [[Category: Berridge, G]] |
| - | [[Category: Burgess-Brown, N | + | [[Category: Burgess-Brown, N]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Krojer, T | + | [[Category: Krojer, T]] |
| - | [[Category: Mahajan, P | + | [[Category: Mahajan, P]] |
| - | [[Category: Murakami, M T | + | [[Category: Murakami, M T]] |
| - | [[Category: Nascimento, A F.Z | + | [[Category: Nascimento, A F.Z]] |
| - | [[Category: Tonoli, C C.C | + | [[Category: Tonoli, C C.C]] |
| - | [[Category: Trindade, D M | + | [[Category: Trindade, D M]] |
[[Category: C-terminal globular tail]] | [[Category: C-terminal globular tail]] | ||
[[Category: Intracellular traffic]] | [[Category: Intracellular traffic]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Vesicle]] | [[Category: Vesicle]] | ||
Revision as of 18:33, 21 December 2014
Structure of the Cargo Binding Domain from Human Myosin Vc
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