3zj7

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{{STRUCTURE_3zj7| PDB=3zj7 | SCENE= }}
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==Crystal structure of strictosidine glucosidase in complex with inhibitor-1==
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===Crystal structure of strictosidine glucosidase in complex with inhibitor-1===
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<StructureSection load='3zj7' size='340' side='right' caption='[[3zj7]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zj7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Devilpepper Devilpepper]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZJ7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1K:(1R,2S,3S,4R,5R)-4-(CYCLOHEXYLAMINO)-5-(HYDROXYMETHYL)CYCLOPENTANE-1,2,3-TRIOL'>C1K</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zj6|3zj6]], [[3zj8|3zj8]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-alpha-(S)-strictosidine_beta-glucosidase 3-alpha-(S)-strictosidine beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.105 3.2.1.105] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zj7 PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/SG1_RAUSE SG1_RAUSE]] Glucosidase specifically involved in alkaloid biosynthesis leading to the accumulation of several alkaloids, including ajmaline, an important plant-derived pharmaceutical used in the therapy of heart disorders.<ref>PMID:22004291</ref>
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*[[Beta-glucosidase|Beta-glucosidase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3zj7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJ7 OCA].
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[[Category: Devilpepper]]
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[[Category: Castiglia, A]]
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==Reference==
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[[Category: Jaeger, V]]
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<references group="xtra"/><references/>
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[[Category: Lin, H]]
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[[Category: Castiglia, A.]]
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[[Category: Panjikar, S]]
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[[Category: Jaeger, V.]]
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[[Category: Rajendran, C]]
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[[Category: Lin, H.]]
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[[Category: Ruppert, M]]
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[[Category: Panjikar, S.]]
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[[Category: Schuebel, H]]
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[[Category: Rajendran, C.]]
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[[Category: Stoeckigt, J]]
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[[Category: Ruppert, M.]]
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[[Category: Wang, M]]
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[[Category: Schuebel, H.]]
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[[Category: Warzecha, H]]
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[[Category: Stoeckigt, J.]]
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[[Category: Xia, L]]
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[[Category: Wang, M.]]
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[[Category: Warzecha, H.]]
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[[Category: Xia, L.]]
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[[Category: Ajmaline]]
[[Category: Ajmaline]]
[[Category: Alkaloid]]
[[Category: Alkaloid]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]

Revision as of 18:43, 21 December 2014

Crystal structure of strictosidine glucosidase in complex with inhibitor-1

3zj7, resolution 2.50Å

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