1t1n

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[[Image:1t1n.jpg|left|200px]]<br /><applet load="1t1n" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1t1n.jpg|left|200px]]
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caption="1t1n, resolution 2.2&Aring;" />
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'''CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN'''<br />
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{{Structure
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|PDB= 1t1n |SIZE=350|CAPTION= <scene name='initialview01'>1t1n</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=CMO:CARBON MONOXIDE'>CMO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1T1N is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Trematomus_newnesi Trematomus newnesi] with <scene name='pdbligand=ACE:'>ACE</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=CMO:'>CMO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1N OCA].
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1T1N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Trematomus_newnesi Trematomus newnesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1N OCA].
==Reference==
==Reference==
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Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question., Mazzarella L, D'Avino R, di Prisco G, Savino C, Vitagliano L, Moody PC, Zagari A, J Mol Biol. 1999 Apr 16;287(5):897-906. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10222199 10222199]
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Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question., Mazzarella L, D'Avino R, di Prisco G, Savino C, Vitagliano L, Moody PC, Zagari A, J Mol Biol. 1999 Apr 16;287(5):897-906. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10222199 10222199]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Trematomus newnesi]]
[[Category: Trematomus newnesi]]
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[[Category: oxygen transport]]
[[Category: oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:08:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:12:30 2008''

Revision as of 12:12, 20 March 2008

Image:1t1n.jpg


PDB ID 1t1n

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN


Overview

As new structural data have become available, somewhat contrasting explanations of the Root effect in fish haemoglobins (Hb) have been provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1 is presented. The structure is similar to that of Root effect fish Hbs from Spot and T. bernacchii, suggesting that the differences in the pH dependence cannot be related to the modulation of the R-state. In comparison to T. bernacchii Hb 1, the role of the three mutations Thr41 (C6)alpha-->Ile, Ala97 (G3)alpha-->Ser and His41 (C7)beta-->Tyr at the alpha1beta2-interface is discussed.

About this Structure

1T1N is a Protein complex structure of sequences from Trematomus newnesi. Full crystallographic information is available from OCA.

Reference

Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question., Mazzarella L, D'Avino R, di Prisco G, Savino C, Vitagliano L, Moody PC, Zagari A, J Mol Biol. 1999 Apr 16;287(5):897-906. PMID:10222199

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