1t1v
From Proteopedia
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| - | [[Image:1t1v.jpg|left|200px]] | + | [[Image:1t1v.jpg|left|200px]] |
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| - | '''Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution''' | + | {{Structure |
| + | |PDB= 1t1v |SIZE=350|CAPTION= <scene name='initialview01'>1t1v</scene>, resolution 1.60Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1T1V is a [ | + | 1T1V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1V OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the glutaredoxin-like protein SH3BGRL3 at 1.6 Angstrom resolution., Nardini M, Mazzocco M, Massaro A, Maffei M, Vergano A, Donadini A, Scartezzini P, Bolognesi M, Biochem Biophys Res Commun. 2004 May 28;318(2):470-6. PMID:[http:// | + | Crystal structure of the glutaredoxin-like protein SH3BGRL3 at 1.6 Angstrom resolution., Nardini M, Mazzocco M, Massaro A, Maffei M, Vergano A, Donadini A, Scartezzini P, Bolognesi M, Biochem Biophys Res Commun. 2004 May 28;318(2):470-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15120624 15120624] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: glutaredoxin; thioredoxin fold; protein 3d-structure; x-ray crystallography]] | [[Category: glutaredoxin; thioredoxin fold; protein 3d-structure; x-ray crystallography]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:12:37 2008'' |
Revision as of 12:12, 20 March 2008
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| , resolution 1.60Å | |||||||
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| Ligands: | , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution
Overview
We report the 1.6 Angstrom resolution crystal structure of SH3BGRL3, a member of a new mammalian protein family of unknown function. The observed "thioredoxin fold" of SH3BGRL3 matches the tertiary structure of glutaredoxins, even in the N-terminal region where the sequence similarity between the two protein families is negligible. In particular, SH3BGRL3 displays structural modifications at the N-terminal Cys-x-x-Cys loop, responsible for glutathione binding and catalysis in glutaredoxins. The loop hosts a six residue insertion, yielding an extra N-terminal-capped helical turn, first observed here for the thioredoxin fold. This, together with deletion of both Cys residues, results in a substantial reshaping of the neighboring cleft, where glutathione is hosted in glutaredoxins. While not active in redox reaction and glutathione binding, SH3BGRL3 may act as an endogenous modulator of glutaredoxin activities by competing, with its fully conserved thioredoxin fold, for binding to yet unknown target proteins.
About this Structure
1T1V is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the glutaredoxin-like protein SH3BGRL3 at 1.6 Angstrom resolution., Nardini M, Mazzocco M, Massaro A, Maffei M, Vergano A, Donadini A, Scartezzini P, Bolognesi M, Biochem Biophys Res Commun. 2004 May 28;318(2):470-6. PMID:15120624
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