1t1u
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1t1u.gif|left|200px]] | + | [[Image:1t1u.gif|left|200px]] |
| - | + | ||
| - | '''Structural Insights and Functional Implications of Choline Acetyltransferase''' | + | {{Structure |
| + | |PDB= 1t1u |SIZE=350|CAPTION= <scene name='initialview01'>1t1u</scene>, resolution 1.55Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] | ||
| + | |GENE= Chat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| + | }} | ||
| + | |||
| + | '''Structural Insights and Functional Implications of Choline Acetyltransferase''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1T1U is a [ | + | 1T1U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1U OCA]. |
==Reference== | ==Reference== | ||
| - | Structural insights and functional implications of choline acetyltransferase., Govindasamy L, Pedersen B, Lian W, Kukar T, Gu Y, Jin S, Agbandje-McKenna M, Wu D, McKenna R, J Struct Biol. 2004 Nov;148(2):226-35. PMID:[http:// | + | Structural insights and functional implications of choline acetyltransferase., Govindasamy L, Pedersen B, Lian W, Kukar T, Gu Y, Jin S, Agbandje-McKenna M, Wu D, McKenna R, J Struct Biol. 2004 Nov;148(2):226-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15477102 15477102] |
[[Category: Choline O-acetyltransferase]] | [[Category: Choline O-acetyltransferase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| Line 24: | Line 33: | ||
[[Category: choline acetyltransferase]] | [[Category: choline acetyltransferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:12:36 2008'' |
Revision as of 12:12, 20 March 2008
| |||||||
| , resolution 1.55Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | Chat (Rattus norvegicus) | ||||||
| Activity: | Choline O-acetyltransferase, with EC number 2.3.1.6 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structural Insights and Functional Implications of Choline Acetyltransferase
Overview
The biosynthetic enzyme for the neurotransmitter acetylcholine, choline acetyltransferase (ChAT) (E.C. 2.3.1.6), is essential for the development and neuronal activities of cholinergic systems involved in many fundamental brain functions. ChAT catalyzes the transfer of an acetyl group from acetyl-coenzyme A to choline to form the neurotransmitter acetylcholine. Since its discovery more than 60 years ago much research has been devoted to the kinetic studies of this enzyme. For the first time we report the crystal structure of rat ChAT (rChAT) to 1.55 A resolution. The structure of rChAT is a monomer and consists of two domains with an interfacial active site tunnel. This structure, with the modeled substrate binding, provides critical insights into the molecular basis for the production of acetylcholine and may further our understanding of disease causing mutations.
About this Structure
1T1U is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structural insights and functional implications of choline acetyltransferase., Govindasamy L, Pedersen B, Lian W, Kukar T, Gu Y, Jin S, Agbandje-McKenna M, Wu D, McKenna R, J Struct Biol. 2004 Nov;148(2):226-35. PMID:15477102
Page seeded by OCA on Thu Mar 20 14:12:36 2008
