1t2l

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[[Image:1t2l.jpg|left|200px]]<br /><applet load="1t2l" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1t2l.jpg|left|200px]]
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caption="1t2l, resolution 2.8&Aring;" />
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'''Three Crystal Structures of Human Coactosin-like Protein'''<br />
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{{Structure
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|PDB= 1t2l |SIZE=350|CAPTION= <scene name='initialview01'>1t2l</scene>, resolution 2.8&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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'''Three Crystal Structures of Human Coactosin-like Protein'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1T2L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2L OCA].
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1T2L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2L OCA].
==Reference==
==Reference==
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Crystal structure of human coactosin-like protein., Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W, J Mol Biol. 2004 Nov 19;344(2):317-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15522287 15522287]
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Crystal structure of human coactosin-like protein., Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W, J Mol Biol. 2004 Nov 19;344(2):317-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15522287 15522287]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: beta-sheet]]
[[Category: beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:09:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:12:57 2008''

Revision as of 12:12, 20 March 2008


PDB ID 1t2l

Drag the structure with the mouse to rotate
, resolution 2.8Å
Coordinates: save as pdb, mmCIF, xml



Three Crystal Structures of Human Coactosin-like Protein


Contents

Overview

Human coactosin-like protein is an actin filament binding protein but does not bind to globular actin. It associates with 5-Lipoxygenase both in vivo and in vitro, playing important roles in modulating the activities of actin and 5-Lipoxygenase. Coactosin counteracts the capping activity of capping protein which inhibits the actin polymerization. We determined the crystal structures of human coactosin-like protein by multi-wavelength anomalous dispersion method. The structure showed a high level of similarity to ADF-H domain, although their amino acid sequences share low degree of homology. A few conserved hydrophobic residues that may contribute to the folding were identified. This structure suggests coactosin-like protein bind to F-actin in a different way from ADF/Cofilin family. Combined with the information from previous mutagenesis studies, the binding sites for F-actin and 5-Lipoxygenase were analyzed, respectively. These two sites are quite close, which might prevent F-actin and 5-Lipoxygenase from binding to coactosin simultaneously.

Disease

Known disease associated with this structure: Cardiomyopathy, dilated, 1M OMIM:[600824]

About this Structure

1T2L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human coactosin-like protein., Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W, J Mol Biol. 2004 Nov 19;344(2):317-23. PMID:15522287

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