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2lt5

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[[Image:2lt5.png|left|200px]]
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==Zymogen-FLG of the onconase==
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<StructureSection load='2lt5' size='340' side='right' caption='[[2lt5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_pipiens Rana pipiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LT5 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lt5 RCSB], [http://www.ebi.ac.uk/pdbsum/2lt5 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Onconase((R)) FL-G zymogen is a 120 residue protein produced by circular permutation of the native Onconase((R)) sequence. In this construction, the wild type N- and C-termini are linked by a 16 residue segment and new N- and C-termini are generated at wild type positions R73 and S72. This novel segment linking the native N- and C-termini is designed to obstruct Onconase's((R)) active site and encloses a cleavage site for the HIV-1 protease. As a first step towards the resolution of its 3D structure and the study of its structure-function relationships, we report here the nearly complete NMR (1)H, (13)C and (15)N resonance chemical shift assignments at pH 5.2 and 35 degrees C (BMRB deposit no 17973). The results presented here clearly show that the structure of the wild type Onconase((R)) is conserved in the FL-G zymogen.
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{{STRUCTURE_2lt5| PDB=2lt5 | SCENE= }}
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(1)H, (13)C and (15)N resonance assignments of the Onconase FL-G zymogen.,Serrano S, Callis M, Vilanova M, Benito A, Laurents DV, Ribo M, Bruix M Biomol NMR Assign. 2012 Mar 4. PMID:22392335<ref>PMID:22392335</ref>
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===Zymogen-FLG of the onconase===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22392335}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2lt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_pipiens Rana pipiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LT5 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017150970</ref><references group="xtra"/>
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[[Category: Rana pipiens]]
[[Category: Rana pipiens]]
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[[Category: Bruix, M.]]
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[[Category: Bruix, M]]
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[[Category: Callis, M.]]
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[[Category: Callis, M]]
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[[Category: Laurents, D V.]]
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[[Category: Laurents, D V]]
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[[Category: Ribo, M.]]
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[[Category: Ribo, M]]
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[[Category: Serrano, S.]]
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[[Category: Serrano, S]]
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[[Category: Vilanova, M.]]
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[[Category: Vilanova, M]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Ribonuclease]]
[[Category: Ribonuclease]]

Revision as of 04:52, 22 December 2014

Zymogen-FLG of the onconase

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