1t3g

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[[Image:1t3g.gif|left|200px]]<br /><applet load="1t3g" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1t3g.gif|left|200px]]
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caption="1t3g, resolution 2.30&Aring;" />
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'''Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL'''<br />
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{{Structure
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|PDB= 1t3g |SIZE=350|CAPTION= <scene name='initialview01'>1t3g</scene>, resolution 2.30&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= IL1RAPL1, OPHN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1T3G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3G OCA].
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1T3G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3G OCA].
==Reference==
==Reference==
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Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL., Khan JA, Brint EK, O'Neill LA, Tong L, J Biol Chem. 2004 Jul 23;279(30):31664-70. Epub 2004 Apr 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15123616 15123616]
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Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL., Khan JA, Brint EK, O'Neill LA, Tong L, J Biol Chem. 2004 Jul 23;279(30):31664-70. Epub 2004 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15123616 15123616]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tlr]]
[[Category: tlr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:09:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:13:17 2008''

Revision as of 12:13, 20 March 2008

Image:1t3g.gif


PDB ID 1t3g

Drag the structure with the mouse to rotate
, resolution 2.30Å
Gene: IL1RAPL1, OPHN4 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL


Contents

Overview

The Toll/interleukin-1 receptor (TIR) domain is conserved in the intracellular regions of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) as well as in several cytoplasmic adapter molecules. This domain has crucial roles in signal transduction by these receptors for host immune response. Here we report the crystal structure at 2.3-A resolution of the TIR domain of human IL-1RAPL, the first structure of a TIR domain of the IL-1R superfamily. There are large structural differences between this TIR domain and that of TLR1 and TLR2. Helix alphaD in IL-1RAPL is almost perpendicular to its equivalent in TLR1 or TLR2. The BB loop contains a hydrogen bond unique to IL-1RAPL between Thr residues at the 8th and 10th positions. The structural and sequence diversity among these domains may be important for specificity in the signal transduction by these receptors. A dimer of the TIR domain of IL-1RAPL is observed in the crystal, although this domain is monomeric in solution. Residues in the dimer interface are mostly unique to IL-1RAPL, which is consistent with the distinct functional roles of this receptor. Our functional studies show IL-1RAPL can activate JNK but not the ERK or the p38 MAP kinases, whereas its close homolog, TIGIRR, cannot activate JNK. Deletion mutagenesis studies show that the activation of JNK by IL-1RAPL does not depend on the integrity of its TIR domain, suggesting a distinct mechanism of signaling through this receptor.

Disease

Known disease associated with this structure: Mental retardation, X-linked, 21/34 OMIM:[300206]

About this Structure

1T3G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL., Khan JA, Brint EK, O'Neill LA, Tong L, J Biol Chem. 2004 Jul 23;279(30):31664-70. Epub 2004 Apr 30. PMID:15123616

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