1t3j

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[[Image:1t3j.jpg|left|200px]]<br /><applet load="1t3j" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1t3j.jpg|left|200px]]
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caption="1t3j, resolution 2.50&Aring;" />
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'''Mitofusin domain HR2 V686M/I708M mutant'''<br />
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{{Structure
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|PDB= 1t3j |SIZE=350|CAPTION= <scene name='initialview01'>1t3j</scene>, resolution 2.50&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= MFN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''Mitofusin domain HR2 V686M/I708M mutant'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1T3J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA].
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1T3J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA].
==Reference==
==Reference==
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Structural basis of mitochondrial tethering by mitofusin complexes., Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, Chan DC, Science. 2004 Aug 6;305(5685):858-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15297672 15297672]
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Structural basis of mitochondrial tethering by mitofusin complexes., Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, Chan DC, Science. 2004 Aug 6;305(5685):858-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15297672 15297672]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: dimer]]
[[Category: dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:09:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:13:19 2008''

Revision as of 12:13, 20 March 2008

Image:1t3j.jpg


PDB ID 1t3j

Drag the structure with the mouse to rotate
, resolution 2.50Å
Gene: MFN1 (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



Mitofusin domain HR2 V686M/I708M mutant


Overview

Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans (that is, between adjacent mitochondria). A heptad repeat region (HR2) mediates mitofusin oligomerization by assembling a dimeric, antiparallel coiled coil. The transmembrane segments are located at opposite ends of the 95 angstrom coiled coil and provide a mechanism for organelle tethering. Consistent with this proposal, truncated mitofusin, in an HR2-dependent manner, causes mitochondria to become apposed with a uniform gap. Our results suggest that HR2 functions as a mitochondrial tether before fusion.

About this Structure

1T3J is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of mitochondrial tethering by mitofusin complexes., Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, Chan DC, Science. 2004 Aug 6;305(5685):858-62. PMID:15297672

Page seeded by OCA on Thu Mar 20 14:13:19 2008

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