1nzg
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine== | |
| - | + | <StructureSection load='1nzg' size='340' side='right' caption='[[1nzg]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | { | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[1nzg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NZG FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ME:2-O-{2-[2-(DIMETHYLAMINO)ETHOXY]ETHYL}-5-METHYLURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>3ME</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nzg RCSB], [http://www.ebi.ac.uk/pdbsum/1nzg PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | [structure: see text] Oligonucleotides with a novel, 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] (2'-O-DMAEOE) modification have been synthesized. This modification, a cationic analogue of the 2'-O-(2-methoxyethyl) (2'-O-MOE) modification, exhibits high binding affinity to target RNA (but not to DNA) and exceptional resistance to nuclease degradation. Analysis of the crystal structure of a self-complementary oligonucleotide containing a single 2'-O-DMAEOE modification explains the importance of charge factors and gauche effects on the observed antisense properties. 2'-O-DMAEOE modified oligonucleotides are ideal candidates for antisense drugs. | ||
| - | + | 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects.,Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M Org Lett. 2003 Jun 12;5(12):2017-20. PMID:12790517<ref>PMID:12790517</ref> | |
| - | [[ | + | |
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Egli, M | + | == References == |
| - | [[Category: Manoharan, M | + | <references/> |
| - | [[Category: Minasov, G | + | __TOC__ |
| - | [[Category: Prakash, T P | + | </StructureSection> |
| - | [[Category: Prhavc, M | + | [[Category: Egli, M]] |
| + | [[Category: Manoharan, M]] | ||
| + | [[Category: Minasov, G]] | ||
| + | [[Category: Prakash, T P]] | ||
| + | [[Category: Prhavc, M]] | ||
[[Category: 2'-modified oligonucleotide]] | [[Category: 2'-modified oligonucleotide]] | ||
[[Category: A-dna]] | [[Category: A-dna]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
Revision as of 04:54, 22 December 2014
Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine
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