1t7s

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[[Image:1t7s.gif|left|200px]]<br /><applet load="1t7s" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1t7s.gif|left|200px]]
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caption="1t7s, resolution 2.80&Aring;" />
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'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''<br />
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{{Structure
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|PDB= 1t7s |SIZE=350|CAPTION= <scene name='initialview01'>1t7s</scene>, resolution 2.80&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= Bag-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])
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}}
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'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1T7S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7S OCA].
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1T7S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7S OCA].
==Reference==
==Reference==
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Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15333932 15333932]
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Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15333932 15333932]
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: psi]]
[[Category: psi]]
[[Category: secsg]]
[[Category: secsg]]
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[[Category: southeast collaboratory for structural genomics]]
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[[Category: southeast collaboratory for structural genomic]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:10:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:14:55 2008''

Revision as of 12:14, 20 March 2008

Image:1t7s.gif


PDB ID 1t7s

Drag the structure with the mouse to rotate
, resolution 2.80Å
Gene: Bag-1 (Caenorhabditis elegans)
Coordinates: save as pdb, mmCIF, xml



Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein


Overview

Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain.

About this Structure

1T7S is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:15333932

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