1tf2

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[[Image:1tf2.jpg|left|200px]]<br /><applet load="1tf2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1tf2.jpg|left|200px]]
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caption="1tf2, resolution 2.90&Aring;" />
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'''Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis'''<br />
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{{Structure
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|PDB= 1tf2 |SIZE=350|CAPTION= <scene name='initialview01'>1tf2</scene>, resolution 2.90&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
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|ACTIVITY=
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|GENE= SECA, DIV+, BSU35300 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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}}
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'''Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TF2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF2 OCA].
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1TF2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF2 OCA].
==Reference==
==Reference==
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A large conformational change of the translocation ATPase SecA., Osborne AR, Clemons WM Jr, Rapoport TA, Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10937-42. Epub 2004 Jul 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15256599 15256599]
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A large conformational change of the translocation ATPase SecA., Osborne AR, Clemons WM Jr, Rapoport TA, Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10937-42. Epub 2004 Jul 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15256599 15256599]
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: translocation]]
[[Category: translocation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:12:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:17:33 2008''

Revision as of 12:17, 20 March 2008

Image:1tf2.jpg


PDB ID 1tf2

Drag the structure with the mouse to rotate
, resolution 2.90Å
Ligands: and
Gene: SECA, DIV+, BSU35300 (Bacillus subtilis)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis


Overview

The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have determined the crystal structure of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A comparison with the previously determined structures of SecA reveals a nucleotide-independent, large conformational change that opens a deep groove similar to that in other proteins that interact with diverse polypeptides. We propose that the open form of SecA represents an activated state.

About this Structure

1TF2 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

A large conformational change of the translocation ATPase SecA., Osborne AR, Clemons WM Jr, Rapoport TA, Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10937-42. Epub 2004 Jul 15. PMID:15256599

Page seeded by OCA on Thu Mar 20 14:17:33 2008

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