1tf6

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[[Image:1tf6.jpg|left|200px]]<br /><applet load="1tf6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1tf6.jpg|left|200px]]
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caption="1tf6, resolution 3.100&Aring;" />
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'''CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION'''<br />
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{{Structure
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|PDB= 1tf6 |SIZE=350|CAPTION= <scene name='initialview01'>1tf6</scene>, resolution 3.100&Aring;
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|SITE= <scene name='pdbsite=AN1:Zn-Binding+Site'>AN1</scene>, <scene name='pdbsite=AN2:Zn-Binding+Site'>AN2</scene>, <scene name='pdbsite=AN3:Zn-Binding+Site'>AN3</scene>, <scene name='pdbsite=AN4:Zn-Binding+Site'>AN4</scene>, <scene name='pdbsite=AN5:Zn-Binding+Site'>AN5</scene>, <scene name='pdbsite=AN6:Zn-Binding+Site'>AN6</scene>, <scene name='pdbsite=DN1:Zn-Binding+Site'>DN1</scene>, <scene name='pdbsite=DN2:Zn-Binding+Site'>DN2</scene>, <scene name='pdbsite=DN3:Zn-Binding+Site'>DN3</scene>, <scene name='pdbsite=DN4:Zn-Binding+Site'>DN4</scene>, <scene name='pdbsite=DN5:Zn-Binding+Site'>DN5</scene> and <scene name='pdbsite=DN6:'Zn-Binding'>DN6</scene>
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TF6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1TF6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Known structural/functional Sites: <scene name='pdbsite=AN1:Zn-Binding+Site'>AN1</scene>, <scene name='pdbsite=AN2:Zn-Binding+Site'>AN2</scene>, <scene name='pdbsite=AN3:Zn-Binding+Site'>AN3</scene>, <scene name='pdbsite=AN4:Zn-Binding+Site'>AN4</scene>, <scene name='pdbsite=AN5:Zn-Binding+Site'>AN5</scene>, <scene name='pdbsite=AN6:Zn-Binding+Site'>AN6</scene>, <scene name='pdbsite=DN1:Zn-Binding+Site'>DN1</scene>, <scene name='pdbsite=DN2:Zn-Binding+Site'>DN2</scene>, <scene name='pdbsite=DN3:Zn-Binding+Site'>DN3</scene>, <scene name='pdbsite=DN4:Zn-Binding+Site'>DN4</scene>, <scene name='pdbsite=DN5:Zn-Binding+Site'>DN5</scene> and <scene name='pdbsite=DN6:'Zn-Binding'>DN6</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF6 OCA].
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1TF6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 1TF6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF6 OCA].
==Reference==
==Reference==
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Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex., Nolte RT, Conlin RM, Harrison SC, Brown RS, Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2938-43. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9501194 9501194]
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Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex., Nolte RT, Conlin RM, Harrison SC, Brown RS, Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2938-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9501194 9501194]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: zinc finger protein]]
[[Category: zinc finger protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:12:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:17:36 2008''

Revision as of 12:17, 20 March 2008

Image:1tf6.jpg


PDB ID 1tf6

Drag the structure with the mouse to rotate
, resolution 3.100Å
Sites: , , , , , , , , , , and
Ligands:
Coordinates: save as pdb, mmCIF, xml



CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION


Overview

The crystal structure of the six NH2-terminal zinc fingers of Xenopus laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA gene promoter has been determined at 3.1 A resolution. Individual zinc fingers are positioned differently in the major groove and across the minor groove of DNA to span the entire length of the duplex. These results show how TFIIIA can recognize several separated DNA sequences by using fewer fingers than necessary for continuous winding in the major groove.

About this Structure

1TF6 is a Single protein structure of sequence from Xenopus laevis. The following page contains interesting information on the relation of 1TF6 with [Zinc Fingers]. Full crystallographic information is available from OCA.

Reference

Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex., Nolte RT, Conlin RM, Harrison SC, Brown RS, Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2938-43. PMID:9501194

Page seeded by OCA on Thu Mar 20 14:17:36 2008

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