1tf7
From Proteopedia
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| - | [[Image:1tf7.jpg|left|200px]] | + | [[Image:1tf7.jpg|left|200px]] |
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| - | '''Crystal Structure of Circadian Clock Protein KaiC''' | + | {{Structure |
| + | |PDB= 1tf7 |SIZE=350|CAPTION= <scene name='initialview01'>1tf7</scene>, resolution 2.8Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= PCC7942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1131 Synechococcus sp.]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Circadian Clock Protein KaiC''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TF7 is a [ | + | 1TF7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF7 OCA]. |
==Reference== | ==Reference== | ||
| - | Visualizing a circadian clock protein: crystal structure of KaiC and functional insights., Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M, Mol Cell. 2004 Aug 13;15(3):375-88. PMID:[http:// | + | Visualizing a circadian clock protein: crystal structure of KaiC and functional insights., Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M, Mol Cell. 2004 Aug 13;15(3):375-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15304218 15304218] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Synechococcus sp.]] | [[Category: Synechococcus sp.]] | ||
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[[Category: homohexamer]] | [[Category: homohexamer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:17:37 2008'' |
Revision as of 12:17, 20 March 2008
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| , resolution 2.8Å | |||||||
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| Ligands: | |||||||
| Gene: | PCC7942 (Synechococcus sp.) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Circadian Clock Protein KaiC
Overview
Circadian (daily) biological clocks express characteristics that are difficult to explain by known biochemical mechanisms, and will ultimately require characterizing the structures, functions, and interactions of their molecular components. KaiC is an essential circadian protein in cyanobacteria that forms the core of the KaiABC clock protein complex. We report the crystal structure of the KaiC homohexameric complex at 2.8 A resolution. The structure resembles a double doughnut with a central pore that is partially sealed at one end. The crystal structure reveals ATP binding, inter-subunit organization, a scaffold for Kai-protein complex formation, the location of critical KaiC mutations, and evolutionary relationships to other proteins. A key auto-phosphorylation site on KaiC (T432) is identified from the crystal structure, and mutation of this residue abolishes circadian rhythmicity. The crystal structure of KaiC will be essential for understanding this circadian clockwork and for establishing its links to global gene expression.
About this Structure
1TF7 is a Single protein structure of sequence from Synechococcus sp.. Full crystallographic information is available from OCA.
Reference
Visualizing a circadian clock protein: crystal structure of KaiC and functional insights., Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M, Mol Cell. 2004 Aug 13;15(3):375-88. PMID:15304218
Page seeded by OCA on Thu Mar 20 14:17:37 2008
Categories: Single protein | Synechococcus sp. | Egli, M. | Johnson, C H. | Mori, T. | Pattanayek, R. | Wang, J. | Xu, Y. | ATP | Hexamer | Homohexamer
