1ti8

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[[Image:1ti8.gif|left|200px]]<br /><applet load="1ti8" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ti8.gif|left|200px]]
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caption="1ti8, resolution 3.00&Aring;" />
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'''H7 Haemagglutinin'''<br />
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{{Structure
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|PDB= 1ti8 |SIZE=350|CAPTION= <scene name='initialview01'>1ti8</scene>, resolution 3.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> and <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''H7 Haemagglutinin'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TI8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=MAN:'>MAN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TI8 OCA].
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1TI8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TI8 OCA].
==Reference==
==Reference==
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H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes., Russell RJ, Gamblin SJ, Haire LF, Stevens DJ, Xiao B, Ha Y, Skehel JJ, Virology. 2004 Aug 1;325(2):287-96. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15246268 15246268]
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H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes., Russell RJ, Gamblin SJ, Haire LF, Stevens DJ, Xiao B, Ha Y, Skehel JJ, Virology. 2004 Aug 1;325(2):287-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15246268 15246268]
[[Category: Influenza a virus]]
[[Category: Influenza a virus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: haemagglutinin]]
[[Category: haemagglutinin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:18:41 2008''

Revision as of 12:18, 20 March 2008

Image:1ti8.gif


PDB ID 1ti8

Drag the structure with the mouse to rotate
, resolution 3.00Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



H7 Haemagglutinin


Overview

Comparing the structures of H3, H5 and H9 subtype haemagglutinins, we deduced a structural basis for including all 15 influenza subtypes in four clades. H3, H5 and H9 represent three of these clades; we now report the structure of an H7 HA as a representative of the fourth clade. We confirm the structure of the turn at the N-terminus of the conserved central alpha-helix of HA2, and the combination of ionisable residues near the "fusion peptide" as clade-specific features. We compare the structures of three H1 HAs with H5 HA in the same clade, to refine our previous classification and we confirm the division of the clades into two groups of two. We also show the roles of carbohydrate side chains in the esterase-fusion domain boundaries in the formation of clade-specific structural markers.

About this Structure

1TI8 is a Protein complex structure of sequences from Influenza a virus. Full crystallographic information is available from OCA.

Reference

H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes., Russell RJ, Gamblin SJ, Haire LF, Stevens DJ, Xiao B, Ha Y, Skehel JJ, Virology. 2004 Aug 1;325(2):287-96. PMID:15246268

Page seeded by OCA on Thu Mar 20 14:18:41 2008

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