1tia

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[[Image:1tia.gif|left|200px]]<br /><applet load="1tia" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1tia.gif|left|200px]]
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caption="1tia, resolution 2.1&Aring;" />
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'''AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES'''<br />
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{{Structure
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|PDB= 1tia |SIZE=350|CAPTION= <scene name='initialview01'>1tia</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3]
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|GENE=
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}}
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'''AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TIA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Penicillium_camemberti Penicillium camemberti]. Active as [http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIA OCA].
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1TIA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Penicillium_camemberti Penicillium camemberti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIA OCA].
==Reference==
==Reference==
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An unusual buried polar cluster in a family of fungal lipases., Derewenda U, Swenson L, Green R, Wei Y, Dodson GG, Yamaguchi S, Haas MJ, Derewenda ZS, Nat Struct Biol. 1994 Jan;1(1):36-47. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7656005 7656005]
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An unusual buried polar cluster in a family of fungal lipases., Derewenda U, Swenson L, Green R, Wei Y, Dodson GG, Yamaguchi S, Haas MJ, Derewenda ZS, Nat Struct Biol. 1994 Jan;1(1):36-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7656005 7656005]
[[Category: Penicillium camemberti]]
[[Category: Penicillium camemberti]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hydrolase(carboxylic esterase)]]
[[Category: hydrolase(carboxylic esterase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:18:42 2008''

Revision as of 12:18, 20 March 2008

Image:1tia.gif


PDB ID 1tia

Drag the structure with the mouse to rotate
, resolution 2.1Å
Activity: Triacylglycerol lipase, with EC number 3.1.1.3
Coordinates: save as pdb, mmCIF, xml



AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES


Overview

The stability of globular proteins arises largely from the burial of non-polar amino acids in their interior. These residues are efficiently packed to eliminate energetically unfavorable cavities. Contrary to these observations, high resolution X-ray crystallographic analyses of four homologous lipases from filamentous fungi reveal an alpha/beta fold which contains a buried conserved constellation of charged and polar side chains with associated cavities containing ordered water molecules. It is possible that this structural arrangement plays an important role in interfacial catalysis.

About this Structure

1TIA is a Single protein structure of sequence from Penicillium camemberti. Full crystallographic information is available from OCA.

Reference

An unusual buried polar cluster in a family of fungal lipases., Derewenda U, Swenson L, Green R, Wei Y, Dodson GG, Yamaguchi S, Haas MJ, Derewenda ZS, Nat Struct Biol. 1994 Jan;1(1):36-47. PMID:7656005

Page seeded by OCA on Thu Mar 20 14:18:42 2008

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