1j75
From Proteopedia
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| - | + | ==Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA== | |
| - | + | <StructureSection load='1j75' size='340' side='right' caption='[[1j75]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[1j75]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J75 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j75 RCSB], [http://www.ebi.ac.uk/pdbsum/1j75 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The first crystal structure of a protein, the Z alpha high affinity binding domain of the RNA editing enzyme ADAR1, bound to left-handed Z-DNA was recently described. The essential set of residues determined from this structure to be critical for Z-DNA recognition was used to search the database for other proteins with the potential for Z-DNA binding. We found that the tumor-associated protein DLM-1 contains a domain with remarkable sequence similarities to Z alpha(ADAR). Here we report the crystal structure of this DLM-1 domain bound to left-handed Z-DNA at 1.85 A resolution. Comparison of Z-DNA binding by DLM-1 and ADAR1 reveals a common structure-specific recognition core within the binding domain. However, the domains differ in certain residues peripheral to the protein-DNA interface. These structures reveal a general mechanism of Z-DNA recognition, suggesting the existence of a family of winged-helix proteins sharing a common Z-DNA binding motif. | ||
| - | + | Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.,Schwartz T, Behlke J, Lowenhaupt K, Heinemann U, Rich A Nat Struct Biol. 2001 Sep;8(9):761-5. PMID:11524677<ref>PMID:11524677</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | + | *[[Z-DNA|Z-DNA]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Behlke, J | + | [[Category: Behlke, J]] |
| - | [[Category: Heinemann, U | + | [[Category: Heinemann, U]] |
| - | [[Category: Lowenhaupt, K | + | [[Category: Lowenhaupt, K]] |
| - | [[Category: Rich, A | + | [[Category: Rich, A]] |
| - | [[Category: Schwartz, T | + | [[Category: Schwartz, T]] |
[[Category: Immune system-dna complex]] | [[Category: Immune system-dna complex]] | ||
[[Category: Protein-z-dna complex]] | [[Category: Protein-z-dna complex]] | ||
Revision as of 06:49, 22 December 2014
Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA
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