1tou

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[[Image:1tou.gif|left|200px]]<br /><applet load="1tou" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1tou.gif|left|200px]]
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caption="1tou, resolution 2.00&Aring;" />
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'''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand'''<br />
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{{Structure
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|PDB= 1tou |SIZE=350|CAPTION= <scene name='initialview01'>1tou</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=B1V:2-[(2-OXO-2-PIPERIDIN-1-YLETHYL)SULFANYL]-6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL'>B1V</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TOU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=B1V:'>B1V</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOU OCA].
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1TOU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOU OCA].
==Reference==
==Reference==
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Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15357970 15357970]
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Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15357970 15357970]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transport]]
[[Category: transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:15:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:21:13 2008''

Revision as of 12:21, 20 March 2008

Image:1tou.gif


PDB ID 1tou

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand


Overview

The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.

About this Structure

1TOU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970

Page seeded by OCA on Thu Mar 20 14:21:13 2008

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