1tow

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[[Image:1tow.gif|left|200px]]<br /><applet load="1tow" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1tow.gif|left|200px]]
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caption="1tow, resolution 2.00&Aring;" />
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'''Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand'''<br />
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{{Structure
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|PDB= 1tow |SIZE=350|CAPTION= <scene name='initialview01'>1tow</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CRZ:4-(9H-CARBAZOL-9-YL)BUTANOIC ACID'>CRZ</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TOW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CRZ:'>CRZ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOW OCA].
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1TOW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOW OCA].
==Reference==
==Reference==
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Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15357969 15357969]
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Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15357969 15357969]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transport]]
[[Category: transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:15:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:21:15 2008''

Revision as of 12:21, 20 March 2008

Image:1tow.gif


PDB ID 1tow

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand


Overview

Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.

About this Structure

1TOW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:15357969

Page seeded by OCA on Thu Mar 20 14:21:15 2008

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