1trj
From Proteopedia
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| - | [[Image:1trj.gif|left|200px]] | + | [[Image:1trj.gif|left|200px]] |
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| - | '''Homology Model of Yeast RACK1 Protein fitted into 11.7A cryo-EM map of Yeast 80S Ribosome''' | + | {{Structure |
| + | |PDB= 1trj |SIZE=350|CAPTION= <scene name='initialview01'>1trj</scene>, resolution 11.70Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Homology Model of Yeast RACK1 Protein fitted into 11.7A cryo-EM map of Yeast 80S Ribosome''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TRJ is a [ | + | 1TRJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TRJ OCA]. |
==Reference== | ==Reference== | ||
| - | Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM., Sengupta J, Nilsson J, Gursky R, Spahn CM, Nissen P, Frank J, Nat Struct Mol Biol. 2004 Oct;11(10):957-62. Epub 2004 Aug 29. PMID:[http:// | + | Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM., Sengupta J, Nilsson J, Gursky R, Spahn CM, Nissen P, Frank J, Nat Struct Mol Biol. 2004 Oct;11(10):957-62. Epub 2004 Aug 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15334071 15334071] |
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ribosome]] | [[Category: ribosome]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:22:13 2008'' |
Revision as of 12:22, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Homology Model of Yeast RACK1 Protein fitted into 11.7A cryo-EM map of Yeast 80S Ribosome
Overview
RACK1 serves as a scaffold protein for a wide range of kinases and membrane-bound receptors. It is a WD-repeat family protein and is predicted to have a beta-propeller architecture with seven blades like a Gbeta protein. Mass spectrometry studies have identified its association with the small subunit of eukaryotic ribosomes and, most recently, it has been shown to regulate initiation by recruiting protein kinase C to the 40S subunit. Here we present the results of a cryo-EM study of the 80S ribosome that positively locate RACK1 on the head region of the 40S subunit, in the immediate vicinity of the mRNA exit channel. One face of RACK1 exposes the WD-repeats as a platform for interactions with kinases and receptors. Using this platform, RACK1 can recruit other proteins to the ribosome.
About this Structure
1TRJ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM., Sengupta J, Nilsson J, Gursky R, Spahn CM, Nissen P, Frank J, Nat Struct Mol Biol. 2004 Oct;11(10):957-62. Epub 2004 Aug 29. PMID:15334071
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