1ttf
From Proteopedia
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| - | [[Image:1ttf.jpg|left|200px]] | + | [[Image:1ttf.jpg|left|200px]] |
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| - | '''THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS''' | + | {{Structure |
| + | |PDB= 1ttf |SIZE=350|CAPTION= <scene name='initialview01'>1ttf</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TTF is a [ | + | 1TTF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTF OCA]. |
==Reference== | ==Reference== | ||
| - | The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions., Main AL, Harvey TS, Baron M, Boyd J, Campbell ID, Cell. 1992 Nov 13;71(4):671-8. PMID:[http:// | + | The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions., Main AL, Harvey TS, Baron M, Boyd J, Campbell ID, Cell. 1992 Nov 13;71(4):671-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1423622 1423622] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:23:05 2008'' |
Revision as of 12:23, 20 March 2008
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THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS
Contents |
Overview
The solution structure of the tenth type III module of fibronectin has been determined using nuclear magnetic resonance techniques. The molecule has a fold similar to that of immunoglobulin domains, with seven beta strands forming two antiparallel beta sheets, which pack against each other. Both beta sheets contribute conserved hydrophobic residues to a compact core. The topology is more similar to that of domain 2 of CD4, PapD, and the extracellular domain of the human growth hormone receptor than to that of immunoglobulin C domains. The module contains an Arg-Gly-Asp sequence known to be involved in cell adhesion. This tripeptide is solvent exposed and lies on a conformationally mobile loop between strands F and G, consistent with its cell adhesion function.
Disease
Known diseases associated with this structure: Ehlers-Danlos syndrome, type X, 225310 (1) OMIM:[135600]
About this Structure
1TTF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions., Main AL, Harvey TS, Baron M, Boyd J, Campbell ID, Cell. 1992 Nov 13;71(4):671-8. PMID:1423622
Page seeded by OCA on Thu Mar 20 14:23:05 2008
